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   Articles with "piggybac transposon" as a keyword



PiggyBac transposon-mediated mutagenesis and application in yeast Komagataella phaffii

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recommendations! Published in 2018 at "Biotechnology Letters"

DOI: 10.1007/s10529-018-2592-6

Abstract: ObjectiveAround one-fourth of the Komagataella phaffii genes encode hypothetical proteins with unknown functions. However, lack of powerful tools for genetic screening in K. phaffii significantly limits the functional analysis of these unknown genes. Transposon mutagenesis… read more here.

Keywords: mutagenesis; piggybac transposon; komagataella phaffii; phaffii ... See more keywords
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Engineered CAR T cells targeting mesothelin by piggyBac transposon system for the treatment of pancreatic cancer.

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recommendations! Published in 2018 at "Cellular immunology"

DOI: 10.1016/j.cellimm.2018.04.007

Abstract: Patients with pancreatic cancer have a poor prognosis largely due to the poor efficacy of the available treatment modalities. In this study, we engineered mesothelin-targeting chimeric antigen receptor T cells (mesoCAR T) using the piggyBac… read more here.

Keywords: cancer; mesothelin; piggybac transposon; pancreatic cancer ... See more keywords
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Generation of a human embryonic stem cell (WAe001-A-47) with hVGLL4 doxycyclin-inducible expression by the PiggyBac transposon system.

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recommendations! Published in 2020 at "Stem cell research"

DOI: 10.1016/j.scr.2020.102142

Abstract: VGLL4 is a new component of the Hippo pathway and bind TEADs to compete with YAP, so as to inhibit tumor progression, but its role in stem cell and organ regeneration remains unclear. Using the… read more here.

Keywords: piggybac transposon; transposon system; stem cell; stem ... See more keywords
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Integrating piggyBac Transposon Transgenes into Mouse Fibroblasts Using Chemical Methods.

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recommendations! Published in 2017 at "Cold Spring Harbor protocols"

DOI: 10.1101/pdb.prot092619

Abstract: Mouse embryonic fibroblasts can be reprogrammed to ES cell-like pluripotent stem cells by the forced expression of four transcription factors-OCT4, SOX2, KLF4, and c-MYC. The piggyBac transposon system has proven effective as a vehicle for… read more here.

Keywords: integrating piggybac; piggybac transposon; transposon transgenes; transposon ... See more keywords