Synthesis of Unsymmetrical Squaramides as Allosteric GSK‐3β Inhibitors Promoting β‐Catenin‐Mediated Transcription of TCF/LEF in Retinal Pigment Epithelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200456
Abstract: The glycogen synthase kinase 3β (GSK‐3β) is a ubiquitous enzyme that is a validated target for the development of potential therapeutics useful in several diseases including retinal degeneration. Aiming at developing an innovative class of… read more here.
Keywords: epithelial cells; pigment epithelial; retinal pigment; tcf lef ... See more keywords
MiR‐455‐5p ameliorates HG‐induced apoptosis, oxidative stress and inflammatory via targeting SOCS3 in retinal pigment epithelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28755
Abstract: Diabetic retinopathy (DR) remains the leading cause of blindness in adults with diabetes mellitus. Numerous microRNAs (miRNAs) have been identified to modulate the pathogenesis of DR. The main purpose of this study was to evaluate… read more here.
Keywords: apoptosis; pigment epithelial; mir 455; stress ... See more keywords
Bevacizumab induces oxidative cytotoxicity and apoptosis via TRPM2 channel activation in retinal pigment epithelial cells: Protective role of glutathione
Sign Up to like & getrecommendations! Published in 2021 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-021-05074-7
Abstract: Bevacizumab (BEV) is a blocker of circulating VEGF A generation. However, BEV has adverse apoptotic and cytotoxic effects via upregulation of mitochondrial reactive oxygen species (ROS) and TRPM2 activation, and downregulation of cytosolic glutathione (GSH)… read more here.
Keywords: pigment epithelial; treatment; gsh; bev ... See more keywords
Essential Role of mTOR Signaling in Human Retinal Pigment Epithelial Cell Regeneration After Laser Photocoagulation
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DOI: 10.1007/s10103-018-2692-5
Abstract: This study assessed the role of mechanistic target of rapamycin (mTOR) pathway in the human adult retinal pigment epithelial (ARPE) cell response after laser photocoagulation (LP). The effect of mTOR inhibition on ARPE-19 cell was… read more here.
Keywords: pigment epithelial; arpe cell; mtor; role ... See more keywords
Retinal pigment epithelial cells reduce vascular leak and proliferation in retinal neovessels
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DOI: 10.1007/s10456-024-09954-4
Abstract: In multiple neurodegenerative diseases, including age-related macular degeneration, retinitis pigmentosa, and macular telangiectasia type 2 (MacTel), retinal pigment epithelial (RPE)-cells proliferate and migrate into the neuroretina, forming intraretinal pigment plaques. Though these pigmentary changes are… read more here.
Keywords: pigment epithelial; retinal pigment; pigment; rpe cells ... See more keywords
Bilateral giant retinal pigment epithelial tears in hypertensive choroidopathy
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Ophthalmology Case Reports"
DOI: 10.1016/j.ajoc.2019.100525
Abstract: Purpose To report a case of hypertensive choroidopathy with bilateral bullous serous retinal detachments (SRDs), retinal pigment epithelial detachments (PEDs), and giant retinal pigment epithelial (RPE) tears. Observations A 68-year-old man with a history of… read more here.
Keywords: pigment epithelial; rpe tears; giant retinal; retinal pigment ... See more keywords
Macular hole and serous pigment epithelial detachment in bilateral acquired vitelliform lesions
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Ophthalmology Case Reports"
DOI: 10.1016/j.ajoc.2020.100628
Abstract: Purpose Acquired vitelliform lesions (AVLs) are associated with age-related macular degeneration and other variable macular disorders. AVLs often lead to outer retinal atrophy, sometimes accompanying a macular hole and choroidal neovascularization. The purpose of this… read more here.
Keywords: vitelliform lesions; pigment epithelial; acquired vitelliform; serous pigment ... See more keywords
Effect of brilliant Blue‐G on cellular stress response in retinal pigment epithelial cells: In vitro
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DOI: 10.1016/j.exer.2019.01.021
Abstract: ABSTRACT To assess the cellular stress evoked by exposure of Brilliant Blue‐G (BBG), adult retinal pigment epithelial (ARPE‐19) cells were treated with various dilutions of BBG in balanced salt solution plus (BSS‐PLUS) with and without… read more here.
Keywords: cell viability; pigment epithelial; stress; cellular stress ... See more keywords
Filtering blue light mitigates the deleterious effects induced by the oxidative stress in human retinal pigment epithelial cells.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental eye research"
DOI: 10.1016/j.exer.2022.108978
Abstract: Age-related macular degeneration (AMD) is a major cause of blindness in elderly. It is characterized by the loss of central vision due to damaged retinal pigment epithelial (RPE) cells and photoreceptors. Blue Light (BL) exposure… read more here.
Keywords: pigment epithelial; blue light; oxidative stress; rpe cells ... See more keywords
Effect of ER stress on sphingolipid levels and apoptotic pathways in retinal pigment epithelial cells
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DOI: 10.1016/j.redox.2020.101430
Abstract: Background We aimed to determine sphingolipid levels and examine apoptotic pathways in human retinal pigment epithelial cells (ARPE-19) undergoing endoplasmic reticulum (ER) stress. Methods Cells were treated with tunicamycin (TM) to induce ER stress and… read more here.
Keywords: protein; sphingolipid levels; apoptotic pathways; pigment epithelial ... See more keywords
Extracellular microparticles exacerbate oxidative damage to retinal pigment epithelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.111957
Abstract: Oxidative stress-induced retinal pigment epithelial cell (RPE) dysfunction is a primary contributing factor to early dry age-related macular degeneration (AMD). Oxidative injury to the retina may promote extracellular vesicles (EVs) released from RPE. In this… read more here.
Keywords: rpe cell; pigment epithelial; rpe cells; retinal pigment ... See more keywords