The pigmented epithelium, a bright partner against photoreceptor degeneration
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurogenetics"
DOI: 10.1080/01677063.2017.1395876
Abstract: Abstract Sight depends on the intimate association between photoreceptors and pigment epithelial cells. The evolutionary origin of this cellular tandem can be traced back to the emergence of bilateral animals, at least 450 million years… read more here.
Keywords: pigmented epithelium; bright partner; photoreceptor degeneration; epithelium bright ... See more keywords
Retina Metabolism and Metabolism in the Pigmented Epithelium: A Busy Intersection.
Sign Up to like & getrecommendations! Published in 2021 at "Annual review of vision science"
DOI: 10.1146/annurev-vision-100419-115156
Abstract: The outer retina is nourished from the choroid, a capillary bed just inside the sclera. O2, glucose, and other nutrients diffuse out of the choroid and then filter through a monolayer of retinal pigment epithelium… read more here.
Keywords: pigmented epithelium; metabolism; retina metabolism; metabolism pigmented ... See more keywords
The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3001924
Abstract: Tissue-specific transcription factors (TFs) control the transcriptome through an association with noncoding regulatory regions (cistromes). Identifying the combination of TFs that dictate specific cell fate, their specific cistromes and examining their involvement in complex human… read more here.
Keywords: retinal pigmented; pigmented epithelium; lhx2; risk ... See more keywords
Generation of retinal pigmented epithelium from iPSCs derived from the conjunctiva of donors with and without age related macular degeneration
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0173575
Abstract: Fidelity in pluripotent stem cell differentiation protocols is necessary for the therapeutic and commercial use of cells derived from embryonic and induced pluripotent stem cells. Recent advances in stem cell technology, especially the widespread availability… read more here.
Keywords: pigmented epithelium; generation; differentiation; generation retinal ... See more keywords