Effect of Solution pH on Distribution of Ophthalmically Administered Brimonidine in Posterior Ocular Tissues in Pigmented Rabbits
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DOI: 10.1007/s40123-019-0180-z
Abstract: IntroductionBrimonidine bioavailability in the aqueous humor depends on the solution pH following topical administration. The purpose of this study was to investigate the effect of solution pH on brimonidine distribution in the posterior ocular tissues… read more here.
Keywords: ocular tissues; posterior ocular; effect solution; solution ... See more keywords
Pharmacological and pharmacokinetic profile of the novel ocular hypotensive prodrug CKLP1 in Dutch-belted pigmented rabbits
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DOI: 10.1371/journal.pone.0231841
Abstract: Elevated intraocular pressure is the only treatable risk factor for glaucoma, an eye disease that is the leading cause of irreversible blindness worldwide. We have identified cromakalim prodrug 1 (CKLP1), a novel water-soluble ATP-sensitive potassium… read more here.
Keywords: cklp1; ocular hypotensive; prodrug cklp1; belted pigmented ... See more keywords