Patient pIgR-enriched extracellular vesicles drive cancer stemness, tumorigenesis and metastasis in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2021.12.005
Abstract: BACKGROUND & AIMS Extracellular vesicles (EVs) play a pivotal role in connecting tumor cells and their local and distant microenvironments. Here, we aimed to understand the role and molecular basis of patient-derived EVs in modulating… read more here.
Keywords: cancer; pigr; hcc; stemness tumorigenesis ... See more keywords
P0724ASSOCIATIONS OF URINARY POLYMERIC IMMUNOGLOBULIN RECEPTOR PEPTIDES IN THE CONTEXT OF CARDIO-RENAL SYNDROM
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa142.p0724
Abstract: The polymeric immunoglobulin receptor (pIgR) which transports immunoglobulins from the basolateral to the apical surface of epithelial cells was recently shown to be associated with kidney dysfunction. The immune defense is initiated at the apical… read more here.
Keywords: pigr; polymeric immunoglobulin; cardio renal; immunoglobulin receptor ... See more keywords
The Underlying Roles of Exosome-Associated PIGR in Fatty Acid Metabolism and Immune Signaling in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/4675683
Abstract: The polymeric immunoglobulin receptor (PIGR), an exosome-associated glycoprotein, plays an important role in the occurrence and development of different tumors. This study aimed to investigate whether PIGR is essential for colorectal cancer (CRC). Comprehensive bioinformatics… read more here.
Keywords: pigr; exosome associated; acid metabolism; colorectal cancer ... See more keywords
Secretory Cells are the Primary Source of pIgR in Small Airways.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2021-0548oc
Abstract: Loss of secretory immunoglobulin A (SIgA) is common in COPD small airways and likely contributes to disease progression. We hypothesized loss of SIgA results from reduced expression of pIgR, a chaperone protein needed for SIgA… read more here.
Keywords: cell; small airways; pigr; loss ... See more keywords
Evolutionary analyses of polymeric immunoglobulin receptor (pIgR) in the mammals reveals an outstanding mutation rate in the lagomorphs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1009387
Abstract: Background The transcytosis of polymeric immunoglobulins, IgA and IgM, across the epithelial barrier to the luminal side of mucosal tissues is mediated by the polymeric immunoglobulin receptor (pIgR). At the luminal side the extracellular ligand… read more here.
Keywords: pigr; immunoglobulin receptor; polymeric immunoglobulin; receptor pigr ... See more keywords
Polymeric immunoglobulin receptor suppresses colorectal cancer through the AKT-FOXO3/4 axis by downregulating LAMB3 expression
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.924988
Abstract: Colorectal cancer (CRC) remains one of the most common malignancies worldwide and its mechanism is unclear. Polymeric immunoglobulin receptor (PIGR) which plays an important role in mucosal immunity is widely expressed in the mucosal epithelium… read more here.
Keywords: pigr; foxo3 axis; immunoglobulin receptor; polymeric immunoglobulin ... See more keywords
Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Medical Sciences"
DOI: 10.7150/ijms.49790
Abstract: Objective: This report aimed to investigate the potential mechanism of polymeric immunoglobulin receptor (PIGR) in promoting cancer development in hepatocellular carcinoma (HCC). Methods: PIGR expression was investigated in Gene Expression Omnibus (GEO), Oncomine, The Cancer… read more here.
Keywords: receptor pigr; polymeric immunoglobulin; group; immunoglobulin receptor ... See more keywords