Joint action of miR‐126 and MAPK/PI3K inhibitors against metastatic melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12506
Abstract: Emerging data support the rationale of combined therapies in advanced melanoma. Specifically, the combined use of drugs with different mechanisms of action can reduce the probability of selecting resistant clones. To identify agents active against… read more here.
Keywords: combination; mir 126; pik; metastatic melanoma ... See more keywords
Diversity and Distribution of Rice Blast (Pyricularia oryzae Cavara) Races in Vietnam.
Sign Up to like & getrecommendations! Published in 2019 at "Plant disease"
DOI: 10.1094/pdis-05-19-1008-re
Abstract: A total of 239 isolates of blast (Pyricularia oryzae Cavara) collected from northern and central Vietnam showed a wide variation in pathogenicity based on the reaction patterns to 25 differential varieties (DVs) harboring 23 resistance… read more here.
Keywords: pik; oryzae cavara; blast pyricularia; piz ... See more keywords
Pathogenicity of Isolates of the Rice Blast Pathogen (Pyricularia oryzae) from Indonesia.
Sign Up to like & getrecommendations! Published in 2020 at "Plant disease"
DOI: 10.1094/pdis-05-20-0949-re
Abstract: A total of 201 isolates of Pyricularia oryzae (the causal agent of rice blast) were collected from three rice ecosystems (upland, lowland, and swampy) in five regions of Indonesia (West Java, Lampung, South Sumatra, Kalimantan,… read more here.
Keywords: pathogenicity; pik; pyricularia oryzae; rice blast ... See more keywords
Membrane Permeant Inhibitor of Myosin Light Chain Kinase Worsens Survival in Murine Polymicrobial Sepsis.
Sign Up to like & getrecommendations! Published in 2021 at "Shock"
DOI: 10.1097/shk.0000000000001759
Abstract: ABSTRACT Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the peri-junctional actin-myosin ring. Genetic deletion of myosin light chain kinase (MLCK) reverses intestinal hyperpermeability and improves… read more here.
Keywords: light chain; myosin; sepsis; pik ... See more keywords
Small-molecule PIK-93 modulates the tumor microenvironment to improve immune checkpoint blockade response
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade9944
Abstract: Immune checkpoint inhibitors (ICIs) targeting PD-L1 immunotherapy are state-of-the-art treatments for advanced non–small cell lung cancer (NSCLC). However, the treatment response of certain patients with NSCLC is unsatisfactory because of an unfavorable tumor microenvironment (TME)… read more here.
Keywords: small molecule; molecule pik; immune checkpoint; tumor microenvironment ... See more keywords
Evaluation of PIK3CA mutations in advanced ER+/HER2-breast cancer in Portugal – U-PIK Project
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1082915
Abstract: Background: Around 40% of ER+/HER2-breast carcinomas (BC) present mutations in the PIK3CA gene. Assessment of PIK3CA mutational status is required to identify patients eligible for treatment with PI3Kα inhibitors, with alpelisib currently the only approved… read more here.
Keywords: pik project; advanced her2; pik; her2 breast ... See more keywords
Effector target-guided engineering of an integrated domain expands the disease resistance profile of a rice NLR immune receptor
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.81123
Abstract: A subset of plant intracellular NLR immune receptors detect effector proteins, secreted by phytopathogens to promote infection, through unconventional integrated domains which resemble the effector’s host targets. Direct binding of effectors to these integrated domains… read more here.
Keywords: domain; pik; nlr immune; effector ... See more keywords