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   Articles with "pik3c3" as a keyword



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MiR-338-5p promotes metastasis of colorectal cancer by inhibition of phosphatidylinositol 3-kinase, catalytic subunit type 3-mediated autophagy pathway

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recommendations! Published in 2019 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2019.04.010

Abstract: Background In our preliminary screening, expression of miR-338-5p was found to be higher in primary colorectal cancer (CRC) with metastasis. The autophagy related gene- phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3) appeared to be targeted… read more here.

Keywords: colorectal cancer; metastasis; phosphatidylinositol kinase; pik3c3 ... See more keywords
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Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseases.

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2214874120

Abstract: Adequate mass and function of adipose tissues (ATs) play essential roles in preventing metabolic perturbations. The pathological reduction of ATs in lipodystrophy leads to an array of metabolic diseases. Understanding the underlying mechanisms may benefit… read more here.

Keywords: brown white; pik3c3; adipose tissues; lipid kinase ... See more keywords
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PIK3C3/VPS34 keeps body fats healthy.

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recommendations! Published in 2023 at "Autophagy"

DOI: 10.1080/15548627.2023.2166275

Abstract: Adipose tissue, or body fat, plays a critical role in the maintenance of health and the development of metabolic diseases. The pathological expansion of adipose tissue during obesity and the pathological reduction of adipose tissue… read more here.

Keywords: pik3c3; pik3c3 vps34; adipose tissue; metabolic diseases ... See more keywords
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Overcoming radio-resistance in esophageal squamous cell carcinoma via hypermethylation of PIK3C3 promoter region mediated by KDM5B loss

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recommendations! Published in 2022 at "Journal of Radiation Research"

DOI: 10.1093/jrr/rrac004

Abstract: Abstract Many patients with esophageal squamous cell carcinoma (ESCC) are inoperable because of old age or the advanced stage of the disease; thus radio- and chemotherapy are believed as the standard treatments for these patients.… read more here.

Keywords: cell; pik3c3; radio resistance; esophageal squamous ... See more keywords
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FoxO1‐AMPK‐ULK1 Regulates Ethanol‐Induced Autophagy in Muscle by Enhanced ATG14 Association with the BECN1‐PIK3C3 Complex

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recommendations! Published in 2017 at "Alcoholism: Clinical and Experimental Research"

DOI: 10.1111/acer.13377

Abstract: BACKGROUND Excessive alcohol (EtOH) consumption causes an imbalance in protein metabolism. EtOH impairs protein synthesis in C2C12 myoblasts via a FoxO1-AMPK-TSC2-mTORC1 pathway and also induces protein degradation. As the underlying regulatory signaling cascades for these… read more here.

Keywords: pik3c3 complex; foxo1 ampk; pik3c3; becn1 ... See more keywords