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   Articles with "pik3ca" as a keyword



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Hémihypertrophie faciale associée à une mutation dans le gène PIK3CA

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recommendations! Published in 2019 at "Annales De Dermatologie Et De Venereologie"

DOI: 10.1016/j.annder.2019.09.392

Abstract: Introduction Les syndromes PIK3CA Related Overgrowth Spectrum (PROS) sont des syndromes hypertrophiques en lien avec une mutation somatique en mosaique du gene PIK3CA. Il s’agit d’un groupe heterogene de pathologies incluant le CLOVES syndrome, le… read more here.

Keywords: une hypertrophie; mutation; mosaique; pik3ca ... See more keywords
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Correlation between PIK3CA mutations in cell-free DNA and everolimus efficacy in HR+, HER2− advanced breast cancer: results from BOLERO-2

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recommendations! Published in 2017 at "British Journal of Cancer"

DOI: 10.1038/bjc.2017.25

Abstract: Background:The current analysis was performed to evaluate the impact of PIK3CA hotspot mutations on everolimus efficacy in BOLERO-2 participants, using cell-free DNA (cfDNA) from plasma samples collected at the time of patient randomisation.Methods:PIK3CA H1047R, E545K,… read more here.

Keywords: dna; everolimus efficacy; free dna; cell free ... See more keywords
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Breast cancer: Changes in clonal dynamics predict response to palbociclib

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recommendations! Published in 2018 at "Nature Reviews Clinical Oncology"

DOI: 10.1038/nrclinonc.2018.42

Abstract: have improved the outcomes of women with advanced-stage oestrogen receptor (ER)-positive breast cancer, although identifying patients who are most likely to respond remains a challenge. Now, the findings of an analysis of plasma samples obtained… read more here.

Keywords: palbociclib; response; treatment; group ... See more keywords
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Somatic PIK3CA mutations are present in multiple tissues of facial infiltrating lipomatosis

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recommendations! Published in 2017 at "Pediatric Research"

DOI: 10.1038/pr.2017.155

Abstract: BackgroundFacial infiltrating lipomatosis (FIL) is a congenital disorder that causes overgrowth of one side of the face. The purpose of this study was to determine whether PIK3CA mutations are present in tissues outside of the… read more here.

Keywords: infiltrating lipomatosis; pik3ca mutations; tissue; mutations present ... See more keywords
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Insulin enhancement of the antitumor activity of chemotherapeutic agents in colorectal cancer is linked with downregulating PIK3CA and GRB2

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-53145-x

Abstract: The present state of cancer chemotherapy is unsatisfactory. New anticancer drugs that marginally improve the survival of patients continue to be developed at an unsustainably high cost. The study aimed to elucidate the effects of… read more here.

Keywords: insulin; chemotherapeutic agents; colon; pik3ca ... See more keywords
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PIK3CA copy number gain and inhibitors of the PI3K/AKT/mTOR pathway in triple-negative breast cancer.

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recommendations! Published in 2023 at "Cold Spring Harbor molecular case studies"

DOI: 10.1101/mcs.a006255

Abstract: As wider insights are gained on the molecular landscape of triple-negative breast cancer (TNBC), novel targeted therapeutic strategies might become an option in this setting as well. Activating mutations of PIK3CA represent the second most… read more here.

Keywords: pi3k akt; pik3ca copy; akt mtor; mtor pathway ... See more keywords
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PIK3CA somatic mutations as potential biomarker for immunotherapy in elder or TP53 mutated gastric cancer patients

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recommendations! Published in 2022 at "Clinical Genetics"

DOI: 10.1111/cge.14260

Abstract: Immune checkpoint inhibitors (ICIs) improve overall survival in patients with advanced gastric cancer (GC). However, the molecular characterization of GC in ICIs responders is unclear. A total of 288 advanced GC patients were included in… read more here.

Keywords: tp53; gastric cancer; somatic mutations; tp53 mutated ... See more keywords
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Frequent PIK3CA activating mutations in nipple adenomas

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recommendations! Published in 2017 at "Histopathology"

DOI: 10.1111/his.13043

Abstract: Nipple adenoma (NA) is a rare benign epithelial tumour occurring in the nipple. Histologically, it exhibits variable and often mixed adenosis‐like and usual ductal hyperplasia‐like growth patterns. Morphologically, it is similar to other benign proliferative… read more here.

Keywords: mutations nipple; frequent pik3ca; nipple adenomas; pik3ca ... See more keywords
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PIK3CA gain-of-function mutation in adipose tissue induces metabolic reprogramming with Warburg-like effect and severe endocrine disruption

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1126/sciadv.ade7823

Abstract: PIK3CA-related overgrowth syndrome (PROS) is a genetic disorder caused by somatic mosaic gain-of-function mutations of PIK3CA. Clinical presentation of patients is diverse and associated with endocrine disruption. Adipose tissue is frequently involved, but its role… read more here.

Keywords: gain function; endocrine disruption; adipose tissue; mutation ... See more keywords
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Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation

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recommendations! Published in 2023 at "Science Advances"

DOI: 10.1126/sciadv.ade8939

Abstract: Somatic activating mutations of PIK3CA are associated with development of vascular malformations (VMs). Here, we describe a microfluidic model of PIK3CA-driven VMs consisting of human umbilical vein endothelial cells expressing PIK3CA activating mutations embedded in… read more here.

Keywords: vascular malformations; role dysregulated; pik3ca driven; model pik3ca ... See more keywords
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Expression and Prognostic Value of PIK3CA, VEGF, IL-8, IL-10, and RIP2 in Diffuse Large B-Cell Lymphoma

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recommendations! Published in 2022 at "International Journal of Clinical Practice"

DOI: 10.1155/2022/2637581

Abstract: Background To explore clinical features and prognostic value of vascular endothelial growth factor (VEGF), interleukin (IL) 8, IL-10, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), and receptor-interacting protein-2 (RIP2) in diffuse large B-cell lymphoma (DLBCL). Methods… read more here.

Keywords: cell; vegf; rip2; serum ... See more keywords