Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation
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DOI: 10.1126/sciadv.ade8939
Abstract: Somatic activating mutations of PIK3CA are associated with development of vascular malformations (VMs). Here, we describe a microfluidic model of PIK3CA-driven VMs consisting of human umbilical vein endothelial cells expressing PIK3CA activating mutations embedded in… read more here.
Keywords: vascular malformations; role dysregulated; pik3ca driven; model pik3ca ... See more keywords