In the literature: February 2022
Sign Up to like & getrecommendations! Published in 2022 at "ESMO Open"
DOI: 10.1016/j.esmoop.2022.100411
Abstract: PIK3CA is one of the most frequently mutated oncogene in cancer. Phosphoinositide 3-kinase (PI3K) is a heterodimer comprising two subunits: a catalytic subunit (p110) and a regulatory subunit (p85). Activating mutations in PIK3CA are found… read more here.
Keywords: cancer; her2; degradation; pik3ca mutant ... See more keywords
PI3K-targeting strategy using alpelisib to enhance the antitumor effect of paclitaxel in human gastric cancer
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68998-w
Abstract: PIK3CA mutations are frequently observed in various human cancers including gastric cancer (GC). This study was conducted to investigate the anti-tumor effects of alpelisib, a PI3K p110α-specific inhibitor, using preclinical models of GC. In addition,… read more here.
Keywords: combination; alpelisib paclitaxel; mutant cells; gastric cancer ... See more keywords
Abstract 3934: Determination of the PI3Kα selective inhibitor alpelisib mechanism of action and efficacy in ER+/ PIK3CA mutant breast cancer preclinical models
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DOI: 10.1158/1538-7445.am2018-3934
Abstract: Over the past years, a key focus has been on identifying inhibitors against components of pathways that drive tumor cell proliferation, survival, and metastasis such as the PI3K/mTOR pathway, known to be implicated in many… read more here.
Keywords: breast cancer; pik3ca; mutant breast; cancer ... See more keywords
Abstract B14: Activation of the MACC1/PIM/cMyc axis confers resistance to PI3K/mTOR inhibition in PIK3CA mutant NSCLC
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.pi3k-mtor18-b14
Abstract: Introduction: The PI3K pathway is often dysregulated in lung cancer, making it an ideal therapeutic target. Pan- and isoform-specific inhibitors of the PI3K pathway are currently being evaluated in clinical trials. However, all patients treated… read more here.
Keywords: pik3ca mutant; resistance pi3k; macc1 pim; pi3k mtor ... See more keywords