Alpelisib for the treatment of PIK3CA-mutated, hormone receptor-positive, HER2-negative metastatic breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2021.1873952
Abstract: ABSTRACT Introduction: Two-thirds of advanced breast cancers are hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative (HR+/HER2-). Gene mutations in PIK3CA, encoding the PI3K catalytic subunit alpha of phosphatidyl-inositol 3-kinase (PI3K), are… read more here.
Keywords: hormone receptor; pik3ca mutated; receptor positive; alpelisib ... See more keywords
Abstract CT046: A phase I basket study of the PI3K inhibitor taselisib (GDC-0032) in PIK3CA-mutated locally advanced or metastatic solid tumors
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DOI: 10.1158/1538-7445.am2018-ct046
Abstract: Background:PIK3CA, a gene that encodes the α-isoform of the catalytic subunit of Class I PI3K (PI3Kα), is frequently mutated or amplified in solid tumors. Taselisib is an oral, potent, selective inhibitor of Class I PI3Kα,… read more here.
Keywords: pi3k; pik3ca mutated; solid tumors; taselisib ... See more keywords
A phase III trial of alpelisib + trastuzumab ± fulvestrant versus trastuzumab + chemotherapy in HER2+ PIK3CA-mutated breast cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Future oncology"
DOI: 10.2217/fon-2022-0045
Abstract: ALPHABET is a randomized phase III trial assessing alpelisib + trastuzumab with or without fulvestrant in previously treated HER2-positive PIK3CA-mutated advanced breast cancer. Patients will be included in two cohorts according to hormone receptor (HR) status. In… read more here.
Keywords: phase iii; alpelisib trastuzumab; breast cancer; trastuzumab ... See more keywords
In vitro anticancer effects of alpelisib against PIK3CA-mutated canine hemangiosarcoma cell lines
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DOI: 10.3892/or.2022.8295
Abstract: Hemangiosarcoma (HSA) is a malignant neoplasm that occurs in humans and canines with a poor prognosis owing to metastatic spread, despite effective treatment. The frequency of spontaneous HSA development is higher in canines than in… read more here.
Keywords: cell lines; canine; hemangiosarcoma; pik3ca mutated ... See more keywords