KRAS , NRAS , BRAF, and PIK3CA mutation rates, clinicopathological association, and their prognostic value in Iranian colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24868
Abstract: Mutations in KRAS, NRAS, BRAF, and PIK3CA genes are critical factors in clinical evaluation of colorectal cancer (CRC) development and progression. In Iran, however, the data regarding genetic profile of CRC patients is limited except… read more here.
Keywords: braf pik3ca; kras nras; pik3ca mutation; colorectal cancer ... See more keywords
Perifosine enhances the potential antitumor effect of 5-fluorourasil and oxaliplatin in colon cancer cells harboring the PIK3CA mutation.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.173957
Abstract: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutation in colon cancer contributes to the poor prognosis of the disease and chemoresistance of tumors. New therapies are needed; however, the lack of knowledge of the mechanism of… read more here.
Keywords: pik3ca mutation; colon cancer; cancer cells;
Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16496-y
Abstract: Lymphatic malformations (LMs) are debilitating vascular anomalies presenting with large cysts (macrocystic) or lesions that infiltrate tissues (microcystic). Cellular mechanisms underlying LM pathology are poorly understood. Here we show that the somatic PIK3CAH1047R mutation, resulting… read more here.
Keywords: lymphatic malformations; pik3ca mutation; blockade vegf; vegf signaling ... See more keywords
PIK3CA mutation profiling in patients with breast cancer, using a highly sensitive detection system
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Science"
DOI: 10.1111/cas.13696
Abstract: PIK3CA mutations are common activating mutations associated with breast cancer (occurring in 20–30% of all cases) and are potent predictive markers for responses to PI3K inhibitors. Thus, it is important to develop sensitive methods to… read more here.
Keywords: detection; system; pik3ca mutation; breast cancer ... See more keywords
Positive association of PIK3CA mutation with KRAS mutation but not BRAF mutation in colorectal cancer suggests co-selection is gene specific but not pathway specific
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Pathology"
DOI: 10.1136/jclinpath-2018-205483
Abstract: Mutation in KRAS, BRAF and PIK3CA are commonly present in colorectal cancer (CRC). KRAS and BRAF form part of the mitogen-activated protein kinase (MAPK) signalling pathway and KRAS lies immediately upstream of BRAF. Consequently, KRAS… read more here.
Keywords: pik3ca mutation; braf; association; mutation braf ... See more keywords
PIK3CA Mutation in the ShortHER Randomized Adjuvant Trial for Patients with Early HER2+ Breast Cancer: Association with Prognosis and Integration with PAM50 Subtype
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-20-1731
Abstract: Purpose: We explored the prognostic effect of PIK3CA mutation in HER2+ patients enrolled in the ShortHER trial. Patients and Methods: The ShortHER trial randomized 1,253 patients with HER2+ breast cancer to 9 weeks or 1… read more here.
Keywords: mutation; pik3ca; cancer; her2 ... See more keywords
Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-17-0867
Abstract: Genetic alterations that potentiate PI3K signaling are frequent in prostate cancer, yet how different genetic drivers of the PI3K cascade contribute to prostate cancer is unclear. Here, we report PIK3CA mutation/amplification correlates with poor survival… read more here.
Keywords: cancer; pik3ca mutation; pten loss; prostate cancer ... See more keywords
Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Diagnostic Pathology"
DOI: 10.1186/s13000-020-01045-4
Abstract: Background Esophageal squamous cell carcinoma (ESCC) still remains intractable disease with few therapeutic options. Programmed death-ligand 1 (PD-L1), which is essential for immune evasion, is involved in the pathogenesis of ESCC and thus is a… read more here.
Keywords: kras braf; msi; pik3ca mutation; hpv ... See more keywords
Prognostic impact of PIK3CA mutation in esophageal cancer: Molecular profiling by next-generation sequencing using formalin-fixed, paraffin-embedded tissues.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e16003
Abstract: e16003Background: The tumor related gene profiling in esophageal cancer is further required to accelerate the development of novel molecular-targeting drugs. The aim of this study was to evaluate g... read more here.
Keywords: esophageal cancer; mutation esophageal; pik3ca mutation; cancer ... See more keywords
Association between PIK3CA mutations and disease-free survival in patients with HR+, HER2- tumors treated with adjuvant hormonal therapy: A real-world study in Croatia.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.e12512
Abstract: e12512 Background: Disease recurrence of early hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast tumor subtype is particularly challenging to manage due to its complex and very heterogeneous biological nature. Namely, due… read more here.
Keywords: treatment; disease recurrence; pik3ca mutation; pik3ca ... See more keywords
Unveiling PIK3CA mutation: a prognostic beacon in endometrial carcinoma and its immune implications
Sign Up to like & getrecommendations! Published in 2025 at "Translational Cancer Research"
DOI: 10.21037/tcr-2025-704
Abstract: Background Endometrial carcinoma (EC) is a prevalent gynecological malignancy with diverse genetic underpinnings. This study aimed to elucidate the prognostic significance of genetic mutations, particularly PIK3CA, and their impact on immune landscape and therapeutic outcomes… read more here.
Keywords: immune; analysis; endometrial carcinoma; pik3ca mutation ... See more keywords