Cancer-Associated PIK3CA Mutations in Overgrowth Disorders
Sign Up to like & getrecommendations! Published in 2018 at "Trends in Molecular Medicine"
DOI: 10.1016/j.molmed.2018.08.003
Abstract: PIK3CA is one of the most commonly mutated genes in solid cancers. PIK3CA mutations are also found in benign overgrowth syndromes, collectively known as PIK3CA-related overgrowth spectrum (PROS). As in cancer, PIK3CA mutations in PROS… read more here.
Keywords: associated pik3ca; pik3ca mutations; mutations overgrowth; cancer ... See more keywords
Somatic PIK3CA mutations are present in multiple tissues of facial infiltrating lipomatosis
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DOI: 10.1038/pr.2017.155
Abstract: BackgroundFacial infiltrating lipomatosis (FIL) is a congenital disorder that causes overgrowth of one side of the face. The purpose of this study was to determine whether PIK3CA mutations are present in tissues outside of the… read more here.
Keywords: infiltrating lipomatosis; pik3ca mutations; tissue; mutations present ... See more keywords
Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors
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DOI: 10.1126/science.aaw9032
Abstract: Seeing double can be a good thing Many human breast cancers harbor activating mutations in PIK3CA, the gene coding for the catalytic subunit of phosphoinositide 3-kinase (PI3K). Clinical trials are underway to evaluate the efficacy… read more here.
Keywords: breast cancers; double pik3ca; pik3ca mutations; pi3k inhibitors ... See more keywords
Biology and Targetability of the Extended Spectrum of PIK3CA Mutations Detected in Breast Carcinoma
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DOI: 10.1158/1078-0432.ccr-22-2115
Abstract: Abstract Purpose: Alpelisib is a PI3K alpha (PI3Kα)-selective inhibitor approved for the treatment of hormone receptor–positive/HER2-negative (HR+/HER2−) PIK3CA-mutated advanced breast cancer (ABC) based on the SOLAR-1 trial, which defined 11 substitutions in exons 7, 9,… read more here.
Keywords: biology targetability; breast; alp ful; pik3ca mutations ... See more keywords
Abstract 1207: A systematic literature review of the prevalence of PIK3CA mutations and mutation hotspots in HR+/HER2- metastatic breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1207
Abstract: Introduction: Clinical research on the predictive value of PIK3CA mutations in hormone receptor-positive (HR+), human epidermal growth factor 2-negative (HER2–) metastatic breast cancer (mBC) has advanced in recent years. However, knowledge of epidemiological prevalence has… read more here.
Keywords: breast; pik3ca mutations; prevalence; pik3ca ... See more keywords
Abstract 2217: Concordance of PIK3CA mutations in hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer: A systematic literature review
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2217
Abstract: Introduction: This systematic literature review sought to determine the concordance of PIK3CA mutations in hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (mBC) patients. Methods: A comprehensive search of PubMed/MEDLINE,… read more here.
Keywords: concordance; pik3ca mutations; cancer; receptor ... See more keywords
Abstract NG16: DoublePIK3CAmutations incisincrease oncogenicity and sensitivity to PI3Kα inhibitors
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DOI: 10.1158/1538-7445.am2020-ng16
Abstract: PIK3CA is the most frequently mutated oncogene across all human cancers, and codes for p110α, the catalytic subunit of the PI3K complex. PI3K catalyzes the phosphorylation of the lipid PIP2 to PIP3, which initiates a… read more here.
Keywords: cancer; pi3k; pik3ca mutations; breast cancer ... See more keywords
Abstract P3-03-01: DoublePIK3CAmutations incisdrive oncogene addiction and enhance sensitivity to PI3K alpha inhibitors in breast cancer
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DOI: 10.1158/1538-7445.sabcs19-p3-03-01
Abstract: Activating mutations in PIK3CA, the gene coding for the catalytic subunit (p110α) of phosphoinositide-3-kinase (PI3K), are the most frequent oncogenic alterations in estrogen receptor-positive (ER+) breast cancer and are also prevalent in other tumor types.… read more here.
Keywords: pik3ca mutations; breast cancer; sensitivity; double pik3ca ... See more keywords
Abstract A21: Compound PIK3CA mutations support a mutational dose-response model for oncogene activation and response to PI3K inhibitor targeted therapy in breast cancer
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DOI: 10.1158/1557-3125.pi3k-mtor18-a21
Abstract: PIK3CA mutations represent the most frequent oncogenic driver lesion found across all human cancers. Given that single PIK3CA mutations are a predictive biomarker for response to PI3K inhibition, and that these clinical benefits are small,… read more here.
Keywords: response; compound; pik3ca; cancer ... See more keywords
PIK3CA Mutations Induce Neuronal Hyperactivity during Glioma Formation.
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DOI: 10.1158/2159-8290.cd-rw2020-019
Abstract: Two glioma driver mutations in PIK3CA promote neuronal hyperactivity via distinct mechanisms. read more here.
Keywords: glioma; induce neuronal; mutations induce; neuronal hyperactivity ... See more keywords
Molecular, Histological, and Clinical Characteristics of Oligodendrogliomas: A Multi-Institutional Retrospective Study
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DOI: 10.1227/neu.0000000000001875
Abstract: BACKGROUND: Reports suggest that phosphatidylinositol 3-kinase pathway alterations confer increased risk of progression and poor prognosis in oligodendroglioma, IDH-mutant, and 1p/19q-codeleted molecular oligodendrogliomas (mODG). However, factors that affect prognosis in mODG have not been thoroughly… read more here.
Keywords: modgs; pfs; pik3ca mutations; radiation ... See more keywords