An integrated investigation of structural and pathway alteration caused by PIK3CA and TP53 mutations identified in cfDNA of metastatic breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30354
Abstract: In peripheral blood, cell‐free DNA (cfDNA) contains circulating tumor DNA (ctDNA), which indicates molecular abnormalities in metastatic breast tumor tissue. The sequencing of cfDNA of Metastatic Breast Cancer (MBC) patients allows assessment of therapy response… read more here.
Keywords: breast cancer; cfdna metastatic; metastatic breast; pik3ca tp53 ... See more keywords
Mutation profiling in the PIK3CA, TP53, and CDKN2A genes in circulating free DNA and impalpable breast lesions.
Sign Up to like & getrecommendations! Published in 2019 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2018.12.008
Abstract: Breast impalpable lesions have become a clinical dilemma because they are small, presenting a heterogeneous cellular phenotype. The aim of this study was to evaluate the mutational profile of the PIK3CA, TP53, and CDKN2A genes,… read more here.
Keywords: tp53 cdkn2a; cdkn2a genes; pik3ca tp53; breast ... See more keywords
Prognostic value of KRAS/TP53/PIK3CA in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Letters"
DOI: 10.3892/ol.2019.10012
Abstract: The present study explored the association between KRAS proto-oncogene GTPase (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA) and tumor protein p53 (TP53) mutations, and the clinical features and survival prognosis in 50 patients with non-small… read more here.
Keywords: tp53 pik3ca; pik3ca tp53; kras tp53; non small ... See more keywords