Genome Editing of Pik3cd Impedes Abnormal Retinal Angiogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Human gene therapy"
DOI: 10.1089/hum.2022.079
Abstract: Abnormal angiogenesis is associated with myriad human diseases including proliferative diabetic retinopathy. Signaling transduction via phosphoinositide 3-kinases (PI3Ks) plays a critical role in angiogenesis. Herein, we showed that p110δ, the catalytic subunit of PI3Kδ, was… read more here.
Keywords: abnormal retinal; retinal angiogenesis; pik3cd; expression ... See more keywords
Overexpression of lncRNA PIK3CD-AS1 promotes expression of LATS1 by competitive binding with microRNA-566 to inhibit the growth, invasion and metastasis of hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Cell International"
DOI: 10.1186/s12935-019-0857-3
Abstract: This study is conducted to investigate the effect of lncRNA PIK3CD-AS1 on the growth and metastasis of hepatocellular carcinoma (HCC) and its potential mechanism. Hepatocellular carcinoma tissues and adjacent normal tissues together with HCC cells… read more here.
Keywords: overexpression; pik3cd; invasion; pik3cd as1 ... See more keywords
A somatic mutation in PIK3CD unravels a novel candidate gene for lymphatic malformation
Sign Up to like & getrecommendations! Published in 2021 at "Orphanet Journal of Rare Diseases"
DOI: 10.1186/s13023-021-01782-9
Abstract: Background Lymphatic malformations (LMs) are benign congenital malformations that stem from the abnormal development of the lymphatic vessels during early embryogenesis. Somatic PIK3CA gene mutations are conventional cause leading to LMs. Both macrocystic and microcystic… read more here.
Keywords: pik3cd; novel candidate; candidate gene; gene ... See more keywords