PIK3R3 is upregulated in liver cancer and activates Akt signaling to control cancer growth by regulation of CDKN1C and SMC1A.
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DOI: 10.1002/cam4.6068
Abstract: BACKGROUND Liver cancer is a highly malignant disease and the third leading cause of cancer death worldwide. Abnormal activation of PI3K/Akt signaling is common in cancer, but whether phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) plays a… read more here.
Keywords: liver cancer; pik3r3; growth; akt signaling ... See more keywords
PIK3R3 Promotes Metastasis of Pancreatic Cancer via ZEB1 Induced Epithelial-Mesenchymal Transition
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DOI: 10.1159/000489382
Abstract: Background/Aims: PIK3R3 is a regulatory subunit of phosphatidylinositol 3-kinase (PI3K) which plays an essential role in the metastasis of several types of cancer. However, whether PIK3R3 can promote the metastasis of pancreatic cancer (PC) is… read more here.
Keywords: pik3r3; pancreatic cancer; zeb1; cancer ... See more keywords
MicroRNA-411 inhibits malignant biological behaviours of colorectal cancer cells by directly targeting PIK3R3.
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DOI: 10.3892/or.2017.6135
Abstract: Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer-related mortality worldwide. Aberrant expression of miRNAs play important roles in the development and progression of various types of cancers… read more here.
Keywords: pik3r3; mir 411; colorectal cancer; expression ... See more keywords