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   Articles with "pikfyve" as a keyword



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Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation.

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recommendations! Published in 2021 at "Pharmacological research"

DOI: 10.1016/j.phrs.2021.105679

Abstract: Sorting nexin 10 (SNX10) has been reported as a critical regulator in macrophage function, and germline SNX10 knockout effectively alleviated mouse colitis. Here, we investigated the precise role of SNX10 in inflammatory responses in macrophages… read more here.

Keywords: pikfyve; mouse colitis; tbk1 rel; rel signaling ... See more keywords
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PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation

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recommendations! Published in 2018 at "Toxicology and Applied Pharmacology"

DOI: 10.1016/j.taap.2018.08.001

Abstract: &NA; PIKfyve phosphoinositide kinase produces PtdIns(3,5)P2 and PtdIns5P and governs a myriad of cellular processes including cytoskeleton rearrangements and cell proliferation. The latter entails rigorous investigation since the cytotoxicity of PIKfyve inhibition is a potential… read more here.

Keywords: excessive cytoplasmic; pikfyve; cytoplasmic vacuolation; inhibitor ... See more keywords
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Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations.

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recommendations! Published in 2019 at "Toxicology and applied pharmacology"

DOI: 10.1016/j.taap.2019.114771

Abstract: Through synthesis of two rare phosphoinositides, PtdIns(3,5)P2 and PtdIns5P, the ubiquitously expressed phosphoinositide kinase PIKfyve is implicated in pleiotropic cellular functions. Small molecules specifically inhibiting PIKfyve activity cause cytoplasmic vacuolation in all dividing cells in… read more here.

Keywords: pikfyve; pikfyve inhibitors; cancer cells; cancer ... See more keywords
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Indolyl-Pyridinyl-Propenone-Induced Methuosis through the Inhibition of PIKFYVE

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recommendations! Published in 2018 at "ACS Omega"

DOI: 10.1021/acsomega.8b00202

Abstract: Methuosis is a form of nonapoptotic cell death characterized by the accumulation of macropinosome-derived vacuoles. Herein, we identify PIKFYVE, a class III phosphoinositide (PI) kinase, as the protein target responsible for the methuosis-inducing activity of… read more here.

Keywords: pikfyve; propenone induced; indolyl pyridinyl; methuosis ... See more keywords

PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity.

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recommendations! Published in 2022 at "Molecular biology of the cell"

DOI: 10.1091/mbc.e21-06-0309

Abstract: Transcriptional factor EB (TFEB) is a master regulator of genes required for autophagy and lysosomal function. The nuclear localization of TFEB is blocked by the mechanistic target of rapamycin complex 1 (mTORC1)-dependent phosphorylation of TFEB at… read more here.

Keywords: phosphorylation; tfeb; pikfyve; mtorc1 ... See more keywords
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Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells

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recommendations! Published in 2021 at "Cancer Research"

DOI: 10.1158/0008-5472.can-20-3371

Abstract: This study demonstrates that PIKfyve and p38MAPK cooperate to regulate lysosome homeostasis and their combined inhibition synergistically blocks autophagy to reduce cancer cell viability in vitro and in vivo. In nutrient-poor conditions, autophagy buffers metabolic… read more here.

Keywords: p38mapk; cancer cells; cancer; pikfyve ... See more keywords
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Abstract 3617: Investigating a role for PIKfyve in cell migration and invasion of clear cell renal cell carcinoma

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-3617

Abstract: Introduction. Clear cell renal cell carcinoma (ccRCC) is the most frequent type of kidney cancer. These highly vascularized tumors are characterized by mutations that inactivate the von Hippel-Lindau (VHL) tumor suppressor gene. About 30 %… read more here.

Keywords: cell; pikfyve; role pikfyve; migration ... See more keywords
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Abstract 201: Roles of PIKfyve in Cardiac Fibroblast Migration

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recommendations! Published in 2019 at "Circulation Research"

DOI: 10.1161/res.125.suppl_1.201

Abstract: Cell migration is fundamental to proper development of the heart as well as other organs. Our characterization of a hypomorphic PIKfyve β-geo/β-geo mouse mutant, revealed that has an abnormally small heart, and raised the possibility… read more here.

Keywords: pikfyve; heart; cell migration; pi3 5p2 ... See more keywords
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Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

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recommendations! Published in 2018 at "Journal of Cell Science"

DOI: 10.1242/jcs.213587

Abstract: ABSTRACT Lysosomes receive and degrade cargo from endocytosis, phagocytosis and autophagy. They also play an important role in sensing and instructing cells on their metabolic state. The lipid kinase PIKfyve generates phosphatidylinositol-3,5-bisphosphate to modulate lysosome… read more here.

Keywords: pikfyve; lysosome enlargement; pikfyve inhibition; inhibition ... See more keywords