Abstract 5502: Androgen blockade confers sensitivity to PIKfyve inhibition in prostate cancer
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DOI: 10.1158/1538-7445.am2023-5502
Abstract: In 2022, 268,490 American men will be diagnosed with prostate cancer and 34,500 men will succumb to its complications. Despite significant advances in prostate cancer treatment over the past few decades, resistance inevitably develops with… read more here.
Keywords: prostate cancer; cancer; pikfyve inhibition;
Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence
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DOI: 10.1242/jcs.213587
Abstract: ABSTRACT Lysosomes receive and degrade cargo from endocytosis, phagocytosis and autophagy. They also play an important role in sensing and instructing cells on their metabolic state. The lipid kinase PIKfyve generates phosphatidylinositol-3,5-bisphosphate to modulate lysosome… read more here.
Keywords: pikfyve; lysosome enlargement; pikfyve inhibition; inhibition ... See more keywords