Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations.
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DOI: 10.1016/j.taap.2019.114771
Abstract: Through synthesis of two rare phosphoinositides, PtdIns(3,5)P2 and PtdIns5P, the ubiquitously expressed phosphoinositide kinase PIKfyve is implicated in pleiotropic cellular functions. Small molecules specifically inhibiting PIKfyve activity cause cytoplasmic vacuolation in all dividing cells in… read more here.
Keywords: pikfyve; pikfyve inhibitors; cancer cells; cancer ... See more keywords