Pilocarpine-Induced Effects on Salivary Secretion as a Pharmacological Biomarker for Cholinergic Parasympathetic Activation.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1048
Abstract: Pilocarpine-induced salivary secretion could serve as a nontherapeutic target engagement biomarker in a clinical setting to test the activity of an M3 positive allosteric modulator (PAM). The potentiating effect on the reactivity of the M3… read more here.
Keywords: pilocarpine; pilocarpine induced; induced effects; effects salivary ... See more keywords
Muscarinic acetylcholine receptor activation synergizes the knockdown and toxicity of GABA‐gated chloride channel insecticides
Sign Up to like & getrecommendations! Published in 2022 at "Pest Management Science"
DOI: 10.1002/ps.7079
Abstract: Abstract BACKGROUND Pest management requires continual identification of new physiological targets and strategies to control pests affecting agriculture and public/animal health. We propose the muscarinic system as a target for agrochemicals because of its physiological… read more here.
Keywords: system; synergism; toxicity; pilocarpine ... See more keywords
Benefits of long-term pilocarpine due to increased muscarinic acetylcholine receptor 3 in salivary glands.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.06.125
Abstract: Hypofunction of the salivary gland causes several life-disrupting side effects such as dental caries, oral candidiasis, loss of taste, and swallowing disorders. No satisfactory therapy has been established to treat salivary hypofunction. Pilocarpine represents a… read more here.
Keywords: administration; pilocarpine; long term; continuous administration ... See more keywords
Transient receptor potential vanilloid 4 is involved in the upregulation of connexin expression following pilocarpine-induced status epilepticus in mice
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2019.07.004
Abstract: Epilepsy is characterized by spontaneous seizures. Changes in the expression of the connexins (Cxs) have been reported to be involved in epileptogenesis. It has previously been shown that the transient receptor potential vanilloid 4 (TRPV4)… read more here.
Keywords: pilocarpine; receptor potential; expression; transient receptor ... See more keywords
Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173377
Abstract: Lithium, commonly used to treat bipolar disorder, potentiates the ability of the muscarinic agonist pilocarpine to induce seizures in rodents. As this potentiation by lithium is reversed by the administration of myo-inositol, the potentiation may… read more here.
Keywords: neural activity; pilocarpine; pilocarpine induced; lithium mimetic ... See more keywords
Targeting PSD95-nNOS interaction by Tat-N-dimer peptide during status epilepticus is neuroprotective in MAM-pilocarpine rat model
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.04.028
Abstract: Glutamate receptors play a crucial pathogenic role in brain damage induced by status epilepticus (SE). SE may initiate NMDAR-dependent excitotoxicity through the production of oxidative damage mediated by the activation of a ternary complex formed… read more here.
Keywords: pilocarpine; psd95 nnos; mam pilocarpine; pilocarpine rat ... See more keywords
Preconditioning with toll-like receptor agonists attenuates seizure activity and neuronal hyperexcitability in the pilocarpine rat model of epilepsy
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.04.020
Abstract: Neuroinflammation plays an important role in epileptic disorders. Toll-like receptors (TLRs) are the key signal transduction tools by which neuroinflammation may promote epileptogenesis. Depending on the stimulus nature, TLRs may engage a distinct signaling pathway.… read more here.
Keywords: toll like; seizure; pilocarpine; rat model ... See more keywords
Pilocarpine 1.25% and the changing landscape of presbyopia treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in ophthalmology"
DOI: 10.1097/icu.0000000000000864
Abstract: PURPOSE OF REVIEW Despite affecting approximately 1.8 billion individuals worldwide, until recently, a pharmacologic treatment for presbyopia was not available. This special commentary reviews the treatment of presbyopia with a focus on the recently approved… read more here.
Keywords: presbyopia; treatment presbyopia; pilocarpine; treatment ... See more keywords
Effect of induced saliva flow on fluid retention time, ruminal microbial yield and methane emission in cattle.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of animal physiology and animal nutrition"
DOI: 10.1111/jpn.13773
Abstract: Both in vitro and animal studies indicated that a higher dilution rate is related to a more efficient microbial synthesis and a lower methane (CH4 ) yield. The latter could be a consequence of the… read more here.
Keywords: ruminal microbial; effect; flow; microbial yield ... See more keywords
A retrospective evaluation of systemic and/or topical pilocarpine treatment for canine neurogenic dry eye: 11 cases.
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary ophthalmology"
DOI: 10.1111/vop.12731
Abstract: OBJECTIVE To assess the response to topical and/or systemic pilocarpine in dogs with neurogenic dry eye. METHOD Medical records of dogs diagnosed with dry eye between 2015 and 2018 were reviewed. Cases were excluded if… read more here.
Keywords: pilocarpine; pilocarpine treatment; topical pilocarpine; treatment ... See more keywords
Evaluation of a Novel Zonular Tension Restoring Accommodating Silicone IOL Design: Pilocarpine and Cyclopentolate-Induced Effect 20 Months after Implantation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Ophthalmology"
DOI: 10.1155/2021/4797851
Abstract: Purpose To investigate a novel zonular-stress restoring accommodating 1-piece silicone IOL. Setting. Angeles City, Philippines. Design Prospective randomized bilateral study. Methods Each patient received a study IOL (ActaLens™, Emmetrope, La Canada, CA) in one eye… read more here.
Keywords: group; iol; novel zonular; silicone iol ... See more keywords