Pilocarpine-Induced Effects on Salivary Secretion as a Pharmacological Biomarker for Cholinergic Parasympathetic Activation.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1048
Abstract: Pilocarpine-induced salivary secretion could serve as a nontherapeutic target engagement biomarker in a clinical setting to test the activity of an M3 positive allosteric modulator (PAM). The potentiating effect on the reactivity of the M3… read more here.
Keywords: pilocarpine; pilocarpine induced; induced effects; effects salivary ... See more keywords
Phase-Dependent Astroglial Alterations in Li–Pilocarpine-Induced Status Epilepticus in Young Rats
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2276-y
Abstract: Epilepsy prevalence is high in infancy and in the elderly population. Lithium–pilocarpine is widely used to induce experimental animal models of epilepsy, leading to similar neurochemical and morphological alterations to those observed in temporal lobe… read more here.
Keywords: induced status; pilocarpine induced; dependent astroglial; status epilepticus ... See more keywords
Identification of microRNA-target genes in mice hippocampus at 1 week after pilocarpine-induced status epilepticus.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.125
Abstract: MicroRNAs (miRNA) are believed to play a crucial role in the cause and treatment of temporal lobe epilepsy (TLE) by controlling gene expression in different stages of the disease. To investigate role of miRNA in… read more here.
Keywords: week pilocarpine; pilocarpine induced; target; status epilepticus ... See more keywords
Beta-caryophyllene attenuates short-term recurrent seizure activity and blood-brain-barrier breakdown after pilocarpine-induced status epilepticus in rats
Sign Up to like & getrecommendations! Published in 2022 at "Brain Research"
DOI: 10.1016/j.brainres.2022.147883
Abstract: BACKGROUND Status epilepticus (SE) is a neurological life-threatening condition, resulting from the failure of the mechanisms responsible for seizure termination. SE is often pharmacoresistant and associated with significant morbidity and mortality. Hence, ceasing or attenuating… read more here.
Keywords: short term; pilocarpine induced; caryophyllene; beta caryophyllene ... See more keywords
Pilocarpine-induced status epilepticus reduces chemosensory control of breathing
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2020.05.002
Abstract: One of the possible causes of death in epilepsy is breathing disorders, especially apneas, which lead to an increase in CO2 levels (hypercapnia) and/or a decrease in O2 levels in arterial blood (hypoxemia). The respiratory… read more here.
Keywords: pilocarpine induced; induced status; respiratory; status epilepticus ... See more keywords
Effects of the putative lithium mimetic ebselen on pilocarpine-induced neural activity.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173377
Abstract: Lithium, commonly used to treat bipolar disorder, potentiates the ability of the muscarinic agonist pilocarpine to induce seizures in rodents. As this potentiation by lithium is reversed by the administration of myo-inositol, the potentiation may… read more here.
Keywords: neural activity; pilocarpine; pilocarpine induced; lithium mimetic ... See more keywords
Withanolide-A treatment exerts a neuroprotective effect via inhibiting neuroinflammation in the hippocampus after pilocarpine-induced status epilepticus
Sign Up to like & getrecommendations! Published in 2020 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2020.106394
Abstract: Status epilepticus (SE) is a medical emergency with high mortality and a risk factor for the development of chronic epilepsy. Given that effective treatments for the pathophysiology following SE are still lacking, suppressing pathophysiological mechanisms… read more here.
Keywords: status epilepticus; pilocarpine induced; treatment; hippocampus ... See more keywords
Rosiglitazone Prevents Autophagy by Regulating Nrf2-Antioxidant Response Element in a Rat Model of Lithium-pilocarpine-induced Status Epilepticus
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.10.026
Abstract: Status epilepticus (SE) leads to irreversible neuronal damage and consists of a complex pathogenesis that involves oxidative stress and subsequent autophagy. Rosiglitazone has recently been considered as a potential neuroprotective factor in epilepsy because of… read more here.
Keywords: status epilepticus; pilocarpine induced; rosiglitazone; lithium pilocarpine ... See more keywords
Glycyrrhizin, an HMGB1 inhibitor, exhibits neuroprotective effects in rats after lithium‐pilocarpine‐induced status epilepticus
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.13040
Abstract: It has been proven that extracellular HMGB1 is involved in progression of neurologic disorders, such as stroke, traumatic brain injury, meningitis and epilepsy. Glycyrrhizin (GL) is a direct inhibitor of HMGB1, and blocks HMGB1 release… read more here.
Keywords: neuroprotective effects; pilocarpine induced; glycyrrhizin; status epilepticus ... See more keywords
Aberrant Connectivity During Pilocarpine-Induced Status Epilepticus
Sign Up to like & getrecommendations! Published in 2020 at "International journal of neural systems"
DOI: 10.1142/s0129065719500291
Abstract: Status epilepticus (SE) is a common, life-threatening neurological disorder that may lead to permanent brain damage. In rodent models, SE is an acute phase of seizures that could be reproduced by injecting with pilocarpine and… read more here.
Keywords: hippocampus thalamus; pilocarpine induced; connectivity; status epilepticus ... See more keywords
N-Methyl-(2S, 4R)-trans-4-hydroxy-L-proline, the major bioactive compound from Sideroxylon obtusifolium, attenuates pilocarpine-induced injury in cultured astrocytes
Sign Up to like & getrecommendations! Published in 2022 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x2022e12381
Abstract: Glial cells have been implicated in temporal lobe epilepsy in humans and in its models. Astrocytes are lost in several brain regions after acute seizures induced by pilocarpine and may suffer hyperplasia at subsequent time… read more here.
Keywords: methyl trans; induced injury; trans hydroxy; pilocarpine induced ... See more keywords