TARGETING HEAT SHOCK PROTEIN 90 AND ITS DOWNSTREAM SIGNALING HUBS FOR THE TREATMENT OF MANTLE CELL LYMPHOMA
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2439_171
Abstract: 21 days. Tumor growth was measured using callipers. Results: PIM1/2/3 were ubiquitously expressed in primary and cultured RS cells but not in healthy donor‐derived peripherial B cells. PIM1/2/3 expression was driven by JAK‐STAT and NFκB… read more here.
Keywords: protein; pim; pim kinases; expression ... See more keywords
Pim‐2 regulates bone resorptive activity of osteoclasts via V‐ATPase a3 isoform expression in periodontal disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30814
Abstract: Cytoplasmic serine/threonine Pim kinases have emerged as important modulators of immune regulation and oncology. However, their regulatory roles in bone remodeling remain obscure. Here, we aimed to determine the roles of Pim kinases in periodontal… read more here.
Keywords: bone; pim; pim kinases; expression ... See more keywords
The upregulation of Pim kinases is essential in coordinating the survival, proliferation, and migration of KIT D816V-mutated neoplastic mast cells.
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia research"
DOI: 10.1016/j.leukres.2019.106166
Abstract: About ˜80% of mast cell neoplasm patients harbor the c-Kit activating mutation D816 V, which is associated with c-Kit inhibitor resistance and poor prognosis. However, the molecular basis for these effects is not fully known. To… read more here.
Keywords: pim; d816; pim kinases; neoplastic mast ... See more keywords
PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
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DOI: 10.1038/s41467-019-09867-7
Abstract: Lentiviruses have evolved to acquire an auxiliary protein Vpx to counteract the intrinsic host restriction factor SAMHD1. Although Vpx is phosphorylated, it remains unclear whether such phosphorylation indeed regulates its activity toward SAMHD1. Here we… read more here.
Keywords: restriction; pim kinases; host; samhd1 ... See more keywords
Microenvironment‐induced PIM kinases promote CXCR4‐triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13632
Abstract: Lymph node microenvironment provides chronic lymphocytic leukaemia (CLL) cells with signals promoting their survival and granting resistance to chemotherapeutics. CLL cells overexpress PIM kinases, which regulate apoptosis, cell cycle and migration. We demonstrate that BCR… read more here.
Keywords: microenvironment; triggered mtor; pim kinases; migration ... See more keywords
PO-095 PIM kinases in the regulation of prostate cancer cell motility
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.137
Abstract: Introduction Pim kinases are constitutively active serine/threonine kinases that are upregulated by the JAK/STAT pathway and are often overexpressed in advanced human haematological and solid cancers. There they have been observed to enhance cancer cell… read more here.
Keywords: cell; prostate cancer; pim kinases; cancer cell ... See more keywords
Abstract B026: PIM kinases regulates tumor associated macrophage survival and inflammatory signaling
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-b026
Abstract: Prostate tumors are highly infiltrated by immunosuppressive tumor associated macrophages (TAMs). TAMs secrete various factors that promote tumor progression and suppress antitumor immunity, making them a promising therapeutic target. PIM kinases are serine/threonine kinases that… read more here.
Keywords: pim kinases; pim; macrophage survival; tumor ... See more keywords
The Role of PIM Kinases in Pediatric Solid Tumors
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DOI: 10.3390/cancers14153565
Abstract: Simple Summary PIM kinases are enzymes that have been identified as potential therapeutic targets in a number of cancers. In this review, we summarize the functions of PIM kinases and the roles they play in… read more here.
Keywords: role pim; pediatric solid; pim kinases; pim ... See more keywords
Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases
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DOI: 10.3390/molecules26216572
Abstract: Pim kinases (proviral integration site for Moloney murine leukemia virus kinases) are overexpressed in various types of hematological malignancies and solid carcinomas, and promote cell proliferation and survival. Thus, Pim kinases are validated as targets… read more here.
Keywords: dibenzofuran derivatives; inspired cercosporamide; pim kinases; derivatives inspired ... See more keywords