PIM1-catalyzed CBX8 phosphorylation promotes the oncogene-induced senescence of human diploid fibroblast.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.070
Abstract: The proto-oncogene PIM1 encodes Ser/Thr kinase and regulates cell growth, differentiation and apoptosis. However, more and more studies including ours have found that PIM1 can induce senescence in normal human diploid fibroblasts and behave as… read more here.
Keywords: pim1; cbx8; senescence; induced senescence ... See more keywords
Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2166936
Abstract: Abstract Bis-thiazole derivatives were synthesised conforming to the Pim1 pharmacophore model following Hantzsch condensation. Pim1 has a major role in regulating the G1/S phase which upon inhibition the cell cycle stops at its early stages.… read more here.
Keywords: thiazole derivatives; bis thiazole; pim1; cytotoxic evaluation ... See more keywords
Duplicate genes as sources for rapid adaptive evolution of sperm under environmental pollution in tree sparrow
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Ecology"
DOI: 10.1111/mec.16833
Abstract: Environmental pollution can result in poor sperm quality either directly or indirectly in birds. However, adaptive and compensatory sperm morphology changes and motility improvements have rapidly evolved in tree sparrows (Passer montanus) inhabiting polluted areas… read more here.
Keywords: evolution sperm; environmental pollution; pim1; tree sparrow ... See more keywords
Polyimidazolium Protects against an Invasive Clinical Isolate of Salmonella Typhimurium
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00597-22
Abstract: Frequent outbreaks of Salmonella Typhimurium infection, in both animal and human populations and with the potential for zoonotic transmission, pose a significant threat to the public health sector. The rapid emergence and spread of more… read more here.
Keywords: salmonella typhimurium; infection; salmonella; pim1 ... See more keywords
SAT0003 PIM1 REGULATES CD4+ T CELL EFFECTOR FUNCTION IN EARLY RHEUMATOID ARTHRITIS AND HAS POTENTIAL FOR USE AS A NOVEL, MEASURABLE THERAPEUTIC TARGET
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.7047
Abstract: Background: We previously showed PIM1, among other STAT3-target genes, to be strikingly upregulated in circulating CD4+ T cells of treatment-naïve ‘early’ rheumatoid arthritis (eRA) patients1,2. PIM1 has a recognised role in T cell development, has… read more here.
Keywords: cd4 cells; pim1; eli lilly; cd4 cell ... See more keywords
Pim1 Overexpression Prevents Apoptosis in Cardiomyocytes After Exposure to Hypoxia and Oxidative Stress via Upregulating Cell Autophagy
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000493817
Abstract: Background/Aims: Microvascular obstruction (MVO), an undesirable complication of percutaneous coronary intervention, is independently associated with adverse left ventricle remodeling and poor prognosis after acute myocardial infarction. Hypoxia and oxidative stress major roles in the pathophysiology… read more here.
Keywords: pim1; apoptosis; exposure hypoxia; hypoxia ... See more keywords
Bromodomain and Extra Terminal Domain (BET) Inhibitors Sensitize Chronic Myelomonocytic Leukemia (CMML) to PIM Inhibition Via Downregulation of Mir-33a
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-128165
Abstract: CMML is a lethal myeloid neoplasm with no therapies that improve its dismal prognosis. Inhibition of BET family members has been proposed as a therapeutic strategy based on preclinical data identifying BRD4 as a therapeutic… read more here.
Keywords: pim1; beti; mir 33a; leukemia ... See more keywords
Investigating single amino acid substitutions in PIM1 kinase: A structural genomics approach
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0258929
Abstract: PIM1, is a serine/threonine proto-oncogene kinase, involved in many biological functions, including cell survival, proliferation, and differentiation, thus play a key role in oncogenesis. It plays a crucial role in the onset and progression of… read more here.
Keywords: amino acid; pim1; investigating single; acid substitutions ... See more keywords
Downregulation of PIM1 regulates glycolysis and suppresses tumor progression in gallbladder cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Management and Research"
DOI: 10.2147/cmar.s184381
Abstract: Background PIM1, a serine/threonine kinase, plays an essential role in tumorigenesis of multiple types of tumors. However, the expression pattern and functions of PIM1 in gallbladder cancer (GBC) remain largely unknown. Materials and methods Immunohistochemistry,… read more here.
Keywords: glycolysis; gallbladder cancer; inhibition pim1; pim1 ... See more keywords
Melatonin inhibits the malignant progression of glioblastoma via regulating miR-16-5p/PIM1.
Sign Up to like & getrecommendations! Published in 2022 at "Current neurovascular research"
DOI: 10.2174/1567202619666220406084947
Abstract: OBJECTIVES Melatonin (MT) is a pineal hormone with antineoplastic potential. This study aims to explore the therapeutic potential and mechanism of MT on glioblastoma (GBM). METHODS A human GBM cell line, LN229 was used for… read more here.
Keywords: via regulating; mir pim1; malignant progression; inhibits malignant ... See more keywords