PIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12192
Abstract: Tristetraprolin (TTP) is an AU‐rich element‐binding protein that regulates mRNA stability and plays important roles in cancer. The mechanisms by which TTP is regulated in breast cancer are poorly understood. Using multiple biochemical approaches, we… read more here.
Keywords: pim2; cancer tumorigenesis; ttp; breast cancer ... See more keywords
Targeting macrophage polarization by inhibiting Pim2 alleviates inflammatory arthritis via metabolic reprogramming
Sign Up to like & getrecommendations! Published in 2025 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-025-01268-9
Abstract: Macrophage polarization and energy metabolic reprogramming play pivotal roles in the onset and progression of inflammatory arthritis. Moreover, although previous studies have reported that the proviral integration of Moloney virus 2 (Pim2) kinase is involved… read more here.
Keywords: inflammatory arthritis; pim2; macrophage polarization; arthritis ... See more keywords
Abstract 6426: Novel mechanism of PIM2 inhibition leads to significant effect on solid tumors
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-6426
Abstract: Background: PIM2 is overexpressed in hematopoietic and solid cancers, and is involved in multiple signaling pathways. In hematologic malignancies, PIM2 has been shown to be a pro-survival factor and demonstrated to be a possible therapeutic… read more here.
Keywords: mechanism; treatment; inhibition; pim2 ... See more keywords
Abstract 3037: Targeting pro-survival MYC oncogene expression in small cell lung cancer and large cell neuroendocrine carcinoma of the lung with a novel small molecule PIM2 inhibitor
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3037
Abstract: Small cell lung cancer (SCLC) and large cell neuroendocrine carcinoma of the lung (LCNEC) are aggressive neuroendocrine carcinomas (NECs) that exhibit frequent chemoresistance and lack effective treatments for relapsed disease. MYC paralogs are frequently amplified… read more here.
Keywords: cancer; lung; cell; myc ... See more keywords
Pivotal role of PIM2 kinase in plasmablast generation and plasma cell survival, opening new treatment options in myeloma.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021014011
Abstract: The differentiation of B cells into plasmablasts (PBs) and then plasma cells (PCs) is associated with extensive cell reprogramming and new cell functions. By using specific inhibition strategies (including a novel morpholino RNA antisense approach),… read more here.
Keywords: pivotal role; pim2 kinase; pim2; role pim2 ... See more keywords
Multicenter validation of PIM3 and PIM2 in Brazilian pediatric intensive care units
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.1036007
Abstract: Objective To validate the PIM3 score in Brazilian PICUs and compare its performance with the PIM2. Methods Observational, retrospective, multicenter study, including patients younger than 16 years old admitted consecutively from October 2013 to September… read more here.
Keywords: pim3; calibration; mortality; risk ... See more keywords
Inhibition of PIM2 in liver cancer decreases tumor cell proliferation in vitro and in vivo primarily through the modulation of cell cycle progression
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Oncology"
DOI: 10.3892/ijo.2019.4936
Abstract: Liver cancer is the fourth leading cause of cancer-related mortality worldwide with limited therapeutic options. Thus, novel treatment strategies are urgently required. While the oncogenic kinase, proviral integration site for Moloney murine leukemia virus 2… read more here.
Keywords: cancer; cell cycle; liver cancer; pim2 ... See more keywords