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Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12192
Abstract: Tristetraprolin (TTP) is an AU‐rich element‐binding protein that regulates mRNA stability and plays important roles in cancer. The mechanisms by which TTP is regulated in breast cancer are poorly understood. Using multiple biochemical approaches, we…
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Keywords:
pim2;
cancer tumorigenesis;
ttp;
breast cancer ... See more keywords
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Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-6426
Abstract: Background: PIM2 is overexpressed in hematopoietic and solid cancers, and is involved in multiple signaling pathways. In hematologic malignancies, PIM2 has been shown to be a pro-survival factor and demonstrated to be a possible therapeutic…
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Keywords:
mechanism;
treatment;
inhibition;
pim2 ... See more keywords
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Published in 2022 at "Blood"
DOI: 10.1182/blood.2021014011
Abstract: The differentiation of B cells into plasmablasts (PBs) and then plasma cells (PCs) is associated with extensive cell reprogramming and new cell functions. By using specific inhibition strategies (including a novel morpholino RNA antisense approach),…
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Keywords:
pivotal role;
pim2 kinase;
pim2;
role pim2 ... See more keywords
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Published in 2022 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.1036007
Abstract: Objective To validate the PIM3 score in Brazilian PICUs and compare its performance with the PIM2. Methods Observational, retrospective, multicenter study, including patients younger than 16 years old admitted consecutively from October 2013 to September…
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Keywords:
pim3;
calibration;
mortality;
risk ... See more keywords
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Published in 2019 at "International Journal of Oncology"
DOI: 10.3892/ijo.2019.4936
Abstract: Liver cancer is the fourth leading cause of cancer-related mortality worldwide with limited therapeutic options. Thus, novel treatment strategies are urgently required. While the oncogenic kinase, proviral integration site for Moloney murine leukemia virus 2…
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Keywords:
cancer;
cell cycle;
liver cancer;
pim2 ... See more keywords