A new pimarane-type diterpene obtained by biotransformation inhibits human HCT-116 colorectal carcinoma through inhibition of LTA4H activity
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DOI: 10.1007/s00044-020-02520-9
Abstract: Chronic inflammation mediated by several markers promotes cancer progression. Leukotriene A4 hydrolase (LTA4H), an inflammatory marker, is highly expressed in colorectal cancer. Therefore, inhibition of LTA4H could reduce the incidence and progression of this cancer… read more here.
Keywords: hct 116; inhibition lta4h; activity; pimarane type ... See more keywords
Cytotoxic pimarane-type diterpenes from the marine sediment-derived fungus Eutypella sp. FS46
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DOI: 10.1080/14786419.2016.1169418
Abstract: Abstract Two new pimarane-type diterpenes, scopararanes H-I (1–2), along with five known ones (3–7) were isolated from the culture broth of a marine sediment-derived fungus Eutypella sp. FS46, which was obtained from the South China… read more here.
Keywords: sediment derived; derived fungus; type diterpenes; fungus eutypella ... See more keywords