Susceptibility of widely diverse influenza a viruses to PB2 polymerase inhibitor pimodivir.
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DOI: 10.1016/j.antiviral.2021.105035
Abstract: Pimodivir exerts an antiviral effect on the early stages of influenza A virus replication by inhibiting the cap-binding function of polymerase basic protein 2 (PB2). In this study, we used a combination of sequence analysis… read more here.
Keywords: pimodivir susceptibility; susceptibility; influenza viruses; viruses pb2 ... See more keywords
Comprehensive Profiling of Mutations to Influenza Virus PB2 That Confer Resistance to the Cap-Binding Inhibitor Pimodivir
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13071196
Abstract: Antivirals are used not only in the current treatment of influenza but are also stockpiled as a first line of defense against novel influenza strains for which vaccines have yet to be developed. Identifying drug… read more here.
Keywords: pb2; inhibitor; pimodivir; resistance ... See more keywords