PIN1 facilitates ubiquitin-mediated degradation of serine/threonine kinase 3 and promotes melanoma development via TAZ activation.
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DOI: 10.1016/j.canlet.2020.11.033
Abstract: The Hippo signaling pathway controls cellular processes including growth, homeostasis, and apoptosis. The kinase STK3 acts upstream in this pathway to activate LATS1/2 kinase, which phosphorylates and inactivates the transcriptional coactivators YAP/TAZ. The dysregulation of… read more here.
Keywords: degradation; hippo signaling; kinase; pin1 facilitates ... See more keywords