Virtual screening identifies a PIN1 inhibitor with possible antiovarian cancer effects
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DOI: 10.1002/jcp.28224
Abstract: Peptidyl‐prolyl cis–trans isomerase, NIMA‐interacting 1 (PIN1) is a peptidyl‐prolyl isomerase that binds phospho‐Ser/Thr‐Pro motifs in proteins and catalyzes the cis–trans isomerization of proline peptide bonds. PIN1 is overexpressed in several cancers including high‐grade serous ovarian… read more here.
Keywords: virtual screening; pin1 inhibitor; screening identifies; cancer ... See more keywords
MicroRNA Biogenesis is Enhanced by Liposome-Encapsulated Pin1 Inhibitor in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Theranostics"
DOI: 10.7150/thno.34588
Abstract: Hepatocellular carcinoma (HCC) is in an urgent need of new, effective therapies to reduce morbidity and mortality. We have previously demonstrated that peptidyl-prolyl cis/trans isomerase Pin1 is a potential target for HCC therapy, due to… read more here.
Keywords: hepatocellular carcinoma; hcc; pin1 inhibitor; api ... See more keywords