Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica"
DOI: 10.1007/s00401-019-02101-0
Abstract: Tumors of the pineal region comprise several different entities with distinct clinical and histopathological features. Whereas some entities predominantly affect adults, pineoblastoma (PB) constitutes a highly aggressive malignancy of childhood with a poor outcome. PBs… read more here.
Keywords: methylation; pineal region; pineal parenchymal; pineal ... See more keywords
Surgical treatment of symptomatic pineal cysts without hydrocephalus—meta-analysis of the published literature
Sign Up to like & getrecommendations! Published in 2021 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-021-05054-0
Abstract: Background To examine published data and assess evidence relating to safety and efficacy of surgical management of symptomatic pineal cysts without hydrocephalus (nhSPC), we performed a systematic review of the literature and meta-analysis. Methods Following… read more here.
Keywords: pineal; pineal cysts; cysts without; symptomatic pineal ... See more keywords
Contrasting effects of vortioxetine and paroxetine on pineal gland biochemistry in a tryptophan-depletion model of depression in female rats
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2017.08.008
Abstract: We studied the effects of the multi-modal antidepressant, vortioxetine and the SSRI, paroxetine on pineal melatonin and monoamine synthesis in a sub-chronic tryptophan (TRP) depletion model of depression based on a low TRP diet. Female… read more here.
Keywords: biochemistry; model depression; pineal; paroxetine pineal ... See more keywords
Reprint of: Contrasting effects of vortioxetine and paroxetine on pineal gland biochemistry in a tryptophan-depletion model of depression in female rats
Sign Up to like & getrecommendations! Published in 2018 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2017.12.010
Abstract: &NA; We studied the effects of the multi‐modal antidepressant, vortioxetine and the SSRI, paroxetine on pineal melatonin and monoamine synthesis in a sub‐chronic tryptophan (TRP) depletion model of depression based on a low TRP diet.… read more here.
Keywords: biochemistry; depletion model; pineal; paroxetine pineal ... See more keywords
Fast-developing fatal diffuse leptomeningeal dissemination of a pineal germinoma in a young child: a case report and literature review.
Sign Up to like & getrecommendations! Published in 2018 at "British journal of neurosurgery"
DOI: 10.1080/02688697.2018.1520804
Abstract: BACKGROUND Intracranial germinomas are uncommon and constitute less than 1% of all intracranial tumors. They usually arise in the midline of the brain, most commonly in the pineal region. Pineal germinomas tend to spread through… read more here.
Keywords: diffuse; pineal germinoma; pineal germinomas; pineal ... See more keywords
24 hour patterning in gene expression of pineal neurosteroid biosynthesis in young chickens (Gallus gallus domesticus L.)
Sign Up to like & getrecommendations! Published in 2020 at "Chronobiology International"
DOI: 10.1080/07420528.2020.1823404
Abstract: ABSTRACT The pineal gland, one of the three equivalent avian biological clock structures, is also the site of intensive neurosteroid synthesis (7α-hydroxypregnenolone and allopregnanolone). Pineal neurosteroid biosynthesis involves six enzymes: cytochrome P450 side-chain cleavage –… read more here.
Keywords: neurosteroid biosynthesis; pineal neurosteroid; pineal; gene ... See more keywords
Melatonin rhythms in the pineal and non-pineal tissues and their physiological implications in subtropical fish
Sign Up to like & getrecommendations! Published in 2017 at "Biological Rhythm Research"
DOI: 10.1080/09291016.2017.1345453
Abstract: Abstract Melatonin (N-acetyl-5-methoxy tryptamine), following discovery from the extracts of bovine pineal gland, has been detected in the pineal as well as several extra-pineal tissues/organs of different vertebrates including fish. The unique feature of melatonin… read more here.
Keywords: subtropical fish; rhythms pineal; pineal; pineal tissues ... See more keywords
Immune‐pineal axis – acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14083
Abstract: Melatonin is well known for its circadian production by the pineal gland, and there is a growing body of data showing that it is also produced by many other cells and organs, including immune cells.… read more here.
Keywords: pineal axis; acute inflammatory; pineal; melatonin synthesis ... See more keywords
Resource: A multi‐species multi‐timepoint transcriptome database and webpage for the pineal gland and retina
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pineal Research"
DOI: 10.1111/jpi.12673
Abstract: The website and database https://snengs.nichd.nih.gov provides RNA sequencing data from multi‐species analysis of the pineal glands from zebrafish (Danio rerio), chicken (White Leghorn), rat (Rattus novegicus), mouse (Mus musculus), rhesus macaque (Macaca mulatta), and human… read more here.
Keywords: resource multi; multi species; pineal; database ... See more keywords
Adult Primary Pineal Alveolar Rhabdomyosarcoma with FOXO1 Gene Rearrangement and OLIG2 Expression: A Rare Case Report and Literature Review
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Surgical Pathology"
DOI: 10.1177/10668969221080076
Abstract: Alveolar rhabdomyosarcoma is a common malignant soft tissue tumor in child and adolescents. Intracranial alveolar rhabdomyosarcoma in adults is rare, especially in the pineal region. We present a case of primary alveolar rhabdomyosarcoma of the… read more here.
Keywords: foxo1 gene; alveolar rhabdomyosarcoma; pathology; pineal ... See more keywords
Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0205883
Abstract: The vertebrate pineal gland is dedicated to the production of the hormone melatonin, which increases at night to influence circadian and seasonal rhythms. This increase is associated with dramatic changes in the pineal transcriptome. Here,… read more here.
Keywords: single cell; pineal; pineal gland; expression ... See more keywords