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   Articles with "pineoblastoma" as a keyword



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WNT-activated embryonal tumors of the pineal region: ectopic medulloblastomas or a novel pineoblastoma subgroup?

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recommendations! Published in 2020 at "Acta Neuropathologica"

DOI: 10.1007/s00401-020-02208-9

Abstract: Pineoblastoma (PB) is a CNS embryonal tumor of childhood with propensity to metastasize and a 5-year overall survival of 61% [5]. Originating from the pineal gland, PBs carry molecular profiles distinct from medulloblastomas (MBs), the… read more here.

Keywords: wnt activated; pineal region; embryonal tumors; pineoblastoma ... See more keywords
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Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma

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recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-05029-3

Abstract: Pineoblastoma is a rare and highly aggressive brain cancer of childhood, histologically belonging to the spectrum of primitive neuroectodermal tumors. Patients with germline mutations in DICER1, a ribonuclease involved in microRNA processing, have increased risk… read more here.

Keywords: recurrent homozygous; microduplication; pineoblastoma; pediatric adult ... See more keywords
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ETMR-06. DISSECTING THE MOLECULAR AND DEVELOPMENTAL BASIS OF PINEOBLASTOMA THROUGH GENOMICS

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recommendations! Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.210

Abstract: Abstract Pineoblastoma (PB) is an aggressive embryonal brain tumor comprising 1% of pediatric CNS tumors. The clinico-molecular heterogeneity and developmental origins underlying PB are poorly understood; therefore, we have assembled a molecular cohort of histologically… read more here.

Keywords: single cell; etmr dissecting; molecular developmental; dissecting molecular ... See more keywords
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Genomic landscape of pineoblastoma.

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recommendations! Published in 2018 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2018.36.15_suppl.2028

Abstract: 2028Background: Pineoblastoma (PB) is a rare but aggressive pediatric brain tumour arising from the pineal gland. Overall survival rates are estimated at 50-60%, with younger patients ( < 5 years old) faring much worse (15-40%)… read more here.

Keywords: landscape pineoblastoma; oncology; genomic landscape; pineoblastoma ... See more keywords