PINK1 siRNA‐loaded poly(lactic‐co‐glycolic acid) nanoparticles provide neuroprotection in a mouse model of photothrombosis‐induced ischemic stroke
Sign Up to like & getrecommendations! Published in 2023 at "Glia"
DOI: 10.1002/glia.24339
Abstract: PTEN‐induced kinase 1 (PINK1) is a well‐known critical marker in the pathway for mitophagy regulation as well as mitochondrial dysfunction. Evidence suggests that mitochondrial dynamics and mitophagy flux play an important role in the development… read more here.
Keywords: ischemic stroke; poly lactic; lactic glycolic; pink1 ... See more keywords
Induction of PINK1/Parkin-Mediated Mitophagy.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/7651_2017_7
Abstract: PINK1/Parkin mitophagy is a key mechanism to contribute mitochondrial quality control, and the defects are thought to be a cause of those Parkinson's disease onsets. Upon loss of mitochondrial membrane potential, PINK1 and Parkin are… read more here.
Keywords: mediated mitophagy; pink1; pink1 parkin; parkin mediated ... See more keywords
Monitoring Mitochondrial Changes by Alteration of the PINK1-Parkin Signaling in Drosophila.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/7651_2017_9
Abstract: Mitochondrial quality control is a key process in tissues with high energy demands, such as the brain and muscles. Recent studies using Drosophila have revealed that the genes responsible for familial forms of juvenile Parkinson's… read more here.
Keywords: monitoring mitochondrial; pink1; changes alteration; mitochondrial changes ... See more keywords
Pink1 −/− Rats Show Early-Onset Swallowing Deficits and Correlative Brainstem Pathology
Sign Up to like & getrecommendations! Published in 2018 at "Dysphagia"
DOI: 10.1007/s00455-018-9896-5
Abstract: Parkinson disease (PD) compromises oropharyngeal swallowing, which negatively affects quality of life and contributes to aspiration pneumonia. Dysphagia often begins early in the disease process, and does not improve with standard therapies. As a result,… read more here.
Keywords: early onset; pathology; swallowing deficits; pink1 ... See more keywords
The Role of Pink1-Mediated Mitochondrial Pathway in Propofol-Induced Developmental Neurotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03359-1
Abstract: The mechanisms underlying propofol-induced toxicity in developing neurons are still unclear. The aim of present study was to explore the role of Pink1 mediated mitochondria pathway in propofol-induced developmental neurotoxicity. The primary Neural Stem Cells… read more here.
Keywords: propofol induced; pink1; pathway propofol; role pink1 ... See more keywords
PINK1 alleviates myocardial hypoxia-reoxygenation injury by ameliorating mitochondrial dysfunction.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.061
Abstract: PTEN inducible kinase-1 (PINK1) mutant induces mitochondrial dysfunction of cells, resulting in an inherited form of Parkinson's disease. However its exact role in the cardiomyocytes is unclear. The present study examined the function of PINK1… read more here.
Keywords: pink1; h9c2 cells; hypoxia reoxygenation; mitochondrial dysfunction ... See more keywords
Two sides of a coin: Physiological significance and molecular mechanisms for damage-induced mitochondrial localization of PINK1 and Parkin
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Research"
DOI: 10.1016/j.neures.2020.03.009
Abstract: In 1998, PARKIN was reported as a causal gene for hereditary recessive Parkinsonism by Kitada, Mizuno, Hattori, and Shimizu et al. Later in 2004, PINK1 was also reported as a causal gene for hereditary recessive… read more here.
Keywords: localization pink1; two sides; pink1; pink1 parkin ... See more keywords
Generation of an induced pluripotent stem cell line (GIBHi003-A) from a Parkinson's disease patient with mutant PINK1 (p. I368N).
Sign Up to like & getrecommendations! Published in 2019 at "Stem cell research"
DOI: 10.1016/j.scr.2019.101607
Abstract: Familial Parkinson's disease (PD) can be caused by deleterious mutations in PINK1 (encoding PINK1) in an autosomal recessive manner. Functional studies suggest that PINK1 works as a regulator of mitochondrial homeostasis. However, how loss of… read more here.
Keywords: line; disease; pink1; stem cell ... See more keywords
Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01092
Abstract: The mitochondrial rhomboid protease PARL regulates mitophagy by balancing intramembrane proteolysis of PINK1 and PGAM5. It has been implicated in the pathogenesis of Parkinson’s disease, but its investigation as a possible therapeutic target is challenging… read more here.
Keywords: ketoamide inhibitors; parl; rhomboid protease; mitochondrial rhomboid ... See more keywords
Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00760-9
Abstract: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the US. Understanding the mechanisms of CRC progression is essential to improve treatment. Mitochondria is the powerhouse for healthy cells. However, in tumor… read more here.
Keywords: growth; pink1; acetyl coa; mitophagy ... See more keywords
PINK1 ameliorates acute-on-chronic liver failure by inhibiting apoptosis through mTORC2/AKT signaling
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death Discovery"
DOI: 10.1038/s41420-022-01021-5
Abstract: Acute-on-chronic liver failure (ACLF) is a lethal syndrome with a remarkable short-term death rate. Even worse, effective internal medicine therapies are currently lacking. Increasing evidence indicates apoptosis plays a critical role in the progression of… read more here.
Keywords: liver failure; apoptosis; pink1; mtorc2 akt ... See more keywords