Evidence of Neurobiological Changes in the Presymptomatic PINK1 Knockout Rat.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Parkinson's disease"
DOI: 10.3233/jpd-171273
Abstract: BACKGROUND Genetic models of Parkinson's disease (PD) coupled with advanced imaging techniques can elucidate neurobiological disease progression, and can help identify early biomarkers before clinical signs emerge. PTEN-induced putative kinase 1 (PINK1) helps protect neurons… read more here.
Keywords: knockout rat; pink1 knockout; pink1; brain ... See more keywords
Analysis of α-Synuclein Pathology in PINK1 Knockout Rat Brains
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2018.01034
Abstract: Mutations in PTEN induced kinase 1 (PINK1) cause autosomal recessive Parkinson’s disease (PD). The main pathological hallmarks of PD are loss of dopaminergic neurons in the substantia nigra pars compacta and the formation of protein… read more here.
Keywords: pink1 knockout; synuclein pathology; synuclein; pathology ... See more keywords
Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010690
Abstract: Parkinson’s Disease (PD) is a brain-degenerative disorder characterized by a progressive loss of midbrain dopamine neurons. Current standard-of-care includes oral administration of Levodopa to address motor symptoms, but this treatment is not disease-modifying. A reduction… read more here.
Keywords: administration; pink1 knockout; pathology; intranasal administration ... See more keywords