Induction of PINK1/Parkin-Mediated Mitophagy.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/7651_2017_7
Abstract: PINK1/Parkin mitophagy is a key mechanism to contribute mitochondrial quality control, and the defects are thought to be a cause of those Parkinson's disease onsets. Upon loss of mitochondrial membrane potential, PINK1 and Parkin are… read more here.
Keywords: mediated mitophagy; pink1; pink1 parkin; parkin mediated ... See more keywords
Monitoring Mitochondrial Changes by Alteration of the PINK1-Parkin Signaling in Drosophila.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/7651_2017_9
Abstract: Mitochondrial quality control is a key process in tissues with high energy demands, such as the brain and muscles. Recent studies using Drosophila have revealed that the genes responsible for familial forms of juvenile Parkinson's… read more here.
Keywords: monitoring mitochondrial; pink1; changes alteration; mitochondrial changes ... See more keywords
Shedding light on mitophagy in neurons: what is the evidence for PINK1/Parkin mitophagy in vivo?
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2692-9
Abstract: Neurons are highly specialised cells with a large bioenergetic demand, and so require a healthy mitochondrial network to function effectively. This network is compromised in many neurological disorders, in which damaged mitochondria accumulate. Dysfunctional mitochondria… read more here.
Keywords: evidence; parkin mitophagy; mitophagy vivo; pink1 parkin ... See more keywords
Matrine promotes liver cancer cell apoptosis by inhibiting mitophagy and PINK1/Parkin pathways
Sign Up to like & getrecommendations! Published in 2018 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-018-0937-7
Abstract: Matrine is a natural alkaloid isolated from the root and stem of the legume plant Sophora. Its anti-proliferative and pro-apoptotic effects on several types of cancer have been well-documented. However, the role of matrine in… read more here.
Keywords: parkin pathways; matrine; pink1 parkin; cell ... See more keywords
Neuronal Mitophagy: Lessons from a Pathway Linked to Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicity Research"
DOI: 10.1007/s12640-019-00060-8
Abstract: Neurons are specialized cells with complex and extended architecture and high energy requirements. Energy in the form of adenosine triphosphate, produced essentially by mitochondrial respiration, is necessary to preserve neuronal morphology, maintain resting potential, fire… read more here.
Keywords: mitophagy lessons; neuronal mitophagy; lessons pathway; pink1 parkin ... See more keywords
PINK1-Parkin alleviates metabolic stress induced by obesity in adipose tissue and in 3T3-L1 preadipocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.199
Abstract: Mitochondria play an important role in cellular metabolism and are closely related with metabolic stress. Recently, several studies have shown that mitophagy mediated by PTEN-induced putative kinase 1 (PINK1) and Parkin may play a critical… read more here.
Keywords: pink1 parkin; 3t3 preadipocytes; adipose tissue; metabolic stress ... See more keywords
PINK1/Parkin-mediated mitophagy is activated to protect against AFB1-induced kidney damage in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2022.109884
Abstract: Aflatoxin B1 (AFB1) is a toxic food pollutant that has extensive deleterious impacts on the kidney. Oxidative stress represents the primary mechanism of AFB1 nephrotoxicity and can also cause mitochondrial damage. Damaged mitochondria can trigger… read more here.
Keywords: damage; kidney damage; mediated mitophagy; parkin mediated ... See more keywords
Increased PINK1/Parkin-mediated mitophagy explains the improved brain protective effects of slow rewarming following hypothermia after cardiac arrest in rats
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113326
Abstract: Cerebral ischemia-reperfusion (I/R) after cardiac arrest (CA) induces mitochondrial dysfunction, and the timely removal of damaged mitochondria by mitophagy is reported to protect against cerebral I/R injury. Therapeutic hypothermia (TH) has become an important component… read more here.
Keywords: hypothermia; slow rewarming; rewarming group; pink1 parkin ... See more keywords
A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling
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DOI: 10.1016/j.isci.2020.101048
Abstract: Summary Early-onset Parkinson's disease-associated PINK1-Parkin signaling maintains mitochondrial health. Therapeutic approaches for enhancing PINK1-Parkin signaling present a potential strategy for treating various diseases caused by mitochondrial dysfunction. We report two chemical enhancers of PINK1-Parkin signaling,… read more here.
Keywords: based high; cell based; parkin signaling; pink1 parkin ... See more keywords
Two sides of a coin: Physiological significance and molecular mechanisms for damage-induced mitochondrial localization of PINK1 and Parkin
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Research"
DOI: 10.1016/j.neures.2020.03.009
Abstract: In 1998, PARKIN was reported as a causal gene for hereditary recessive Parkinsonism by Kitada, Mizuno, Hattori, and Shimizu et al. Later in 2004, PINK1 was also reported as a causal gene for hereditary recessive… read more here.
Keywords: localization pink1; two sides; pink1; pink1 parkin ... See more keywords
Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01092
Abstract: The mitochondrial rhomboid protease PARL regulates mitophagy by balancing intramembrane proteolysis of PINK1 and PGAM5. It has been implicated in the pathogenesis of Parkinson’s disease, but its investigation as a possible therapeutic target is challenging… read more here.
Keywords: ketoamide inhibitors; parl; rhomboid protease; mitochondrial rhomboid ... See more keywords