SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1643185
Abstract: ABSTRACT The ubiquitination of mitochondrial proteins labels damaged mitochondria for degradation through mitophagy. We recently developed an in vivo system in which mitophagy is slowed by inhibiting mitochondrial division through knockout of Dnm1l/Drp1, a dynamin… read more here.
Keywords: pink1 prkn; prkn parkin; mitochondrial ubiquitination; mitophagy ... See more keywords
Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells.
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1990515
Abstract: Lacking a self-contained metabolism network, viruses have evolved multiple mechanisms for rewiring the metabolic system of their host to hijack the host's metabolic resources for replication. Newcastle disease virus (NDV) is a paramyxovirus, as an… read more here.
Keywords: disease virus; pink1 prkn; metabolism; prkn dependent ... See more keywords