Pinocembrin, a novel histidine decarboxylase inhibitor with anti‐allergic potential in in vitro
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.08.012
Abstract: ABSTRACT Pinocembrin (5, 7‐ dihydroxy flavanone) is the most abundant chiral flavonoid found in propolis, exhibiting antioxidant, antimicrobial and anti‐inflammatory properties. However, the effect of Pinocembrin on allergic response is unexplored. Thus, current study aimed… read more here.
Keywords: pinocembrin; histidine decarboxylase; inhibitor; response ... See more keywords
Pinocembrin mediates antiarrhythmic effects in rats with isoproterenol-induced cardiac remodeling.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2022.174799
Abstract: BACKGROUND High levels of circulating catecholamines are related to raise risk of cardiac arrhythmias. In addition, our recent studies have suggested that pinocembrin could decrease the susceptibility to arrhythmias in several rat models, including chronic… read more here.
Keywords: isoproterenol induced; pinocembrin mediates; cardiac remodeling; mediates antiarrhythmic ... See more keywords
Pinocembrin attenuates allergic airway inflammation via inhibition of NF‐&kgr;B pathway in mice
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.10.005
Abstract: Abstract Pinocembrin, one of the primary flavonoids in propolis, possesses many biological activities, including anti‐inflammation, anti‐oxidation and immunoregulation. This study aimed to evaluate whether pinocembrin could attenuate ovalbumin (OVA)‐induced allergic airway inflammation in mice and… read more here.
Keywords: pinocembrin; allergic airway; inhibition; inflammation ... See more keywords
Optimization of Pinocembrin Biosynthesis in Saccharomyces cerevisiae
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DOI: 10.1021/acssynbio.2c00425
Abstract: The flavonoid pinocembrin and its derivatives have gained increasing interest for their benefits on human health. While pinocembrin and its derivatives can be produced in engineered Saccharomyces cerevisiae, yields remain low. Here, we describe novel… read more here.
Keywords: pinocembrin biosynthesis; biosynthesis saccharomyces; pinocembrin; optimization pinocembrin ... See more keywords
Activation of Sirtuin-1 by Pinocembrin Treatment Contributes to Reduced Early Brain Injury after Subarachnoid Hemorrhage
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DOI: 10.1155/2022/2242833
Abstract: Subarachnoid hemorrhage (SAH) as a devastating neurological disorder is closely related to heightened oxidative insults and neuroinflammatory injury. Pinocembrin, a bioflavonoid, exhibits different biological functions, such as immunomodulatory, anti-inflammatory, antioxidative, and cerebroprotective activities. Herein, we… read more here.
Keywords: subarachnoid hemorrhage; pinocembrin treatment; pinocembrin; injury ... See more keywords
Bioactivity Evaluation of Pinocembrin Derivatives From Penthorum chinense Pursh Stems
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DOI: 10.1177/1934578x19875892
Abstract: The extract of Penthorum chinense Pursh (PCP), a well-known Miao herb medicine, has been used as a key component for a Chinese patented drug to treat several kinds of liver-related diseases. In this work, 3… read more here.
Keywords: penthorum chinense; chinense pursh; pinocembrin; pinocembrin derivatives ... See more keywords
The Prophylactic Effect of Pinocembrin Against Doxorubicin-Induced Cardiotoxicity in an In Vitro H9c2 Cell Model
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DOI: 10.3389/fphar.2020.01172
Abstract: Background The clinical use of Doxorubicin (Dox) is significantly limited by its dose-dependent cardiotoxic side effect. Accumulative evidence suggests that the use of flavonoids, such as the antioxidative Pinocembrin (Pin), could be effective in the… read more here.
Keywords: pinocembrin; induced cardiotoxicity; effect; dox ... See more keywords
Pinocembrin ameliorates atrial fibrillation susceptibility in rats with anxiety disorder induced by empty bottle stimulation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1004888
Abstract: Background: Anxiety disorder (AD) is the most common mental disorder, which is closely related to atrial fibrillation (AF) and is considered to be a trigger of AF. Pinocembrin has been demonstrated to perform a variety… read more here.
Keywords: disorder rats; anxiety disorder; pinocembrin; empty bottle ... See more keywords
Molecular Targets of Pinocembrin Underlying Its Regenerative Activities in Human Keratinocytes
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DOI: 10.3390/ph15080954
Abstract: Pinocembrin is one of the well-known compounds in the group of flavonoids. The pharmacological activities of pinocembrin in association with wound-healing activities have been reported. However, its effects on the aspect of cellular interaction underlying… read more here.
Keywords: human keratinocytes; targets pinocembrin; proliferation; pinocembrin underlying ... See more keywords