PINTology: A short history of the lncRNA LINC‐PINT in different diseases
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1705
Abstract: LINC‐PINT is a p53‐induced long intergenic noncoding transcript that plays a crucial role in many diseases, especially cancer. This long noncoding RNA (lncRNA) gene produces in total 102 (LNCipedia) alternatively spliced variants (LINC‐PINT:1 to LINC‐PINT:102).… read more here.
Keywords: history lncrna; pint; linc pint; pintology short ... See more keywords
A lncRNA survey finds increases in neuroprotective LINC‐PINT in Parkinson’s disease substantia nigra
Sign Up to like & getrecommendations! Published in 2020 at "Aging Cell"
DOI: 10.1111/acel.13115
Abstract: Recent reports highlight regulatory functions of long noncoding RNAs (lncRNAs) in neurodegeneration and aging, but biomedical implications remain limited. Here, we report an rRNA‐depletion‐based long RNA‐Sequencing Resource of 65 substantia nigra, amygdala, and medial temporal… read more here.
Keywords: linc pint; parkinson disease; substantia nigra; pint ... See more keywords
The Small RNA PinT Contributes to PhoP-Mediated Regulation of the Salmonella Pathogenicity Island 1 Type III Secretion System in Salmonella enterica Serovar Typhimurium
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bacteriology"
DOI: 10.1128/jb.00312-19
Abstract: Salmonella is one of the most important food-borne pathogens, infecting over one million people in the United States every year. These bacteria use a needle-like device to interact with intestinal epithelial cells, leading to invasion… read more here.
Keywords: system; small rna; pint; invasion ... See more keywords
Long noncoding RNA LINC-PINT promotes proliferation through EZH2 and predicts poor prognosis in clear cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s202938
Abstract: Background: Renal cell carcinoma (RCC) is one of the most common types of urological malignant tumors. Despite recent advances in diagnosis and management of RCC, its prognosis remains poor. Emerging evidence has shown that long… read more here.
Keywords: linc pint; pint; cell; ezh2 ... See more keywords
Clinical implications of lncRNA LINC-PINT in cancer
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DOI: 10.3389/fmolb.2023.1097694
Abstract: Long noncoding RNAs (lncRNAs) possess the potential for therapeutic targeting to treat many disorders, including cancers. Several RNA-based therapeutics (ASOs and small interfering RNAs) have gained FDA approval over the past decade. And with their… read more here.
Keywords: clinical implications; lncrna linc; pint; linc pint ... See more keywords
LINC-PINT suppresses cisplatin resistance in gastric cancer by inhibiting autophagy activation via epigenetic silencing of ATG5 by EZH2
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.968223
Abstract: Resistance to cisplatin (DDP) is a major obstacle in the clinical treatment of advanced gastric cancer (GC). Long noncoding RNA (lncRNA) play a significant regulatory role in the development and drug resistance of GC. In… read more here.
Keywords: ezh2; pint; linc pint; ddp ... See more keywords