Pioneer Factor Improves CRISPR‐Based C‐To‐G and C‐To‐T Base Editing
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202957
Abstract: Base editing events in eukaryote require a compatible chromatin environment, but there is little research on how chromatin factors contribute to the editing efficiency or window. By engineering BEs (base editors) fused with various pioneer… read more here.
Keywords: editing efficiency; pioneer; base editing; efficiency ... See more keywords
A locust embryo as predictive developmental neurotoxicity testing system for pioneer axon pathway formation.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of toxicology"
DOI: 10.1007/s00204-020-02929-6
Abstract: Exposure to environmental chemicals during in utero and early postnatal development can cause a wide range of neurological defects. Since current guidelines for identifying developmental neurotoxic chemicals depend on the use of large numbers of… read more here.
Keywords: navigation; pioneer axon; locust; developmental neurotoxicity ... See more keywords
Representativeness of the PIONEER-HF Clinical Trial Population in Patients Hospitalized with Heart Failure
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiac Failure"
DOI: 10.1016/j.cardfail.2019.07.436
Abstract: Introduction In the PIONEER-HF trial, the in-hospital initiation of sacubitril/valsartan in patients hospitalized for acute decompensated heart failure (ADHF) was well-tolerated and led to a greater reduction in N-terminal pro-B natriuretic peptide compared with enalapril,… read more here.
Keywords: pioneer; population; pioneer trial; failure ... See more keywords
Adalimumab alleviates skin pain in patients with moderate‐to‐severe hidradenitis suppurativa: Secondary efficacy results from the PIONEER I and PIONEER II randomized controlled trials
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Academy of Dermatology"
DOI: 10.1016/j.jaad.2018.05.015
Abstract: To the Editor: Skin pain among patients with hidradenitis suppurativa (HS) is prevalent, severe, and a recommended target for treatment. Adalimumab has been approved for moderate-to-severe HS in the United States and Europe on the… read more here.
Keywords: adalimumab alleviates; hidradenitis suppurativa; pain; moderate severe ... See more keywords
Catalytic-Independent Functions of PARP-1 Determine Sox2 Pioneer Activity at Intractable Genomic Loci.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.01.017
Abstract: Pioneer transcription factors (TFs) function as genomic first responders, binding to inaccessible regions of chromatin to promote enhancer formation. The mechanism by which pioneer TFs gain access to chromatin remains an important unanswered question. Here… read more here.
Keywords: pioneer activity; genomic loci; intractable genomic; activity ... See more keywords
Dwight Emary Harken, MD, an all-American surgical giant: Pioneer cardiac surgeon, teacher, mentor
Sign Up to like & getrecommendations! Published in 2018 at "Baylor University Medical Center Proceedings"
DOI: 10.1080/08998280.2018.1471896
Abstract: I cannot deny the fact that it is difficult for me to describe my first teacher in cardiac surgery. It is as if you have come face to face with a sheer granite cliff and… read more here.
Keywords: surgeon; dwight emary; cardiac; harken american ... See more keywords
TRANSDIRE: data-driven direct reprogramming by a pioneer factor-guided trans-omics approach
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac209
Abstract: MOTIVATION Direct reprogramming involves the direct conversion of fully differentiated mature cell types into various other cell types while bypassing an intermediate pluripotent state (e.g., induced pluripotent stem cells). Cell differentiation by direct reprogramming is… read more here.
Keywords: trans omics; cell types; pioneer; direct reprogramming ... See more keywords
Pax7 pioneer factor action requires both paired and homeo DNA binding domains
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab561
Abstract: Abstract The pioneer transcription factor Pax7 contains two DNA binding domains (DBD), a paired and a homeo domain. Previous work on Pax7 and the related Pax3 showed that each DBD binds a cognate DNA sequence,… read more here.
Keywords: dna; paired homeo; dna binding; pioneer ... See more keywords
Facilitation by pioneer shrubs for the ecological restoration of riparian forests in the Central Andes of Colombia
Sign Up to like & getrecommendations! Published in 2017 at "Restoration Ecology"
DOI: 10.1111/rec.12490
Abstract: Riparian vegetation has great functional importance in agroscapes because it establishes physical connections between natural ecosystems embedded in an agricultural matrix. Throughout the tropics, the historical demand for cropland and pastures in the lands adjacent… read more here.
Keywords: restoration riparian; pioneer shrubs; facilitation; restoration ... See more keywords
Abstract 4316: Disruption and restoration of pioneer transcription factor hub function in bladder cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4316
Abstract: Urothelial bladder cancer is characterized by the failure to complete transitional epithelial-differentiation. The mechanisms underlying this failure are unknown. To address this gap in knowledge, we analyzed 2000 genes differentially expressed between normal bladder vs.… read more here.
Keywords: bladder cancer; function; bladder; blca ... See more keywords
Abstract 4515: PIONEER: harnessing multi-omics data to enhance immunotherapeutic target discovery and development
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4515
Abstract: Introduction: Immunotherapeutic strategies have produced remarkable results in some malignancies. However, optimal cell surface targets in many childhood cancers remain elusive and tools for novel target discovery are limited. We developed a proteogenomic approach to… read more here.
Keywords: target discovery; development; cancer; pioneer ... See more keywords