A locust embryo as predictive developmental neurotoxicity testing system for pioneer axon pathway formation.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of toxicology"
DOI: 10.1007/s00204-020-02929-6
Abstract: Exposure to environmental chemicals during in utero and early postnatal development can cause a wide range of neurological defects. Since current guidelines for identifying developmental neurotoxic chemicals depend on the use of large numbers of… read more here.
Keywords: navigation; pioneer axon; locust; developmental neurotoxicity ... See more keywords
ccd-5, a novel cdk-5 binding partner, regulates pioneer axon guidance in the ventral nerve cord of Caenorhabditis elegans.
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac024
Abstract: During nervous system development, axons navigate complex environments to reach synaptic targets. Early extending axons must interact with guidance cues in the surrounding tissue, while later extending axons can interact directly with earlier "pioneering" axons,… read more here.
Keywords: nerve cord; ventral nerve; guidance; caenorhabditis elegans ... See more keywords
Retrograde Ret signaling controls sensory pioneer axon outgrowth
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.46092
Abstract: The trafficking mechanisms and transcriptional targets downstream of long-range neurotrophic factor ligand/receptor signaling that promote axon growth are incompletely understood. Zebrafish carrying a null mutation in a neurotrophic factor receptor, Ret, displayed defects in peripheral… read more here.
Keywords: growth; pioneer; axon outgrowth; pioneer axon ... See more keywords