Genetic determinants and epigenetic effects of pioneer factor occupancy
Sign Up to like & getrecommendations! Published in 2017 at "Nature genetics"
DOI: 10.1038/s41588-017-0034-3
Abstract: Transcription factors (TFs) direct developmental transitions by binding to target DNA sequences, influencing gene expression and establishing complex gene-regultory networks. To systematically determine the molecular components that enable or constrain TF activity, we investigated the… read more here.
Keywords: genetic determinants; pioneer factor; determinants epigenetic; effects pioneer ... See more keywords
The pioneer factor hypothesis is not necessary to explain ectopic liver gene activation.
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.73358
Abstract: The Pioneer Factor Hypothesis (PFH) states that pioneer factors (PFs) are a subclass of transcription factors (TFs) that bind to and open inaccessible sites and then recruit non-pioneer factors (nonPFs) that activate batteries of silent… read more here.
Keywords: gene activation; factor hypothesis; pioneer factor; pioneer ... See more keywords