The LEAFY floral regulator displays pioneer transcription factor properties.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular plant"
DOI: 10.1016/j.molp.2021.03.004
Abstract: Pioneer transcription factors (TFs) are a special category of TFs with the capacity to bind to closed chromatin regions in which DNA is wrapped around histones and may be highly methylated. Subsequently, pioneer TFs are… read more here.
Keywords: pioneer transcription; chromatin; leafy floral; floral regulator ... See more keywords
Nucleosome binding by the pioneer transcription factor OCT4
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68850-1
Abstract: Transcription factor binding to genomic DNA is generally prevented by nucleosome formation, in which the DNA is tightly wrapped around the histone octamer. In contrast, pioneer transcription factors efficiently bind their target DNA sequences within… read more here.
Keywords: pioneer transcription; transcription; oct4; nucleosome binding ... See more keywords
Pioneer transcription factors in chromatin remodeling: The kinetic proofreading view.
Sign Up to like & getrecommendations! Published in 2020 at "Physical Review E"
DOI: 10.1103/physreve.101.040401
Abstract: Pioneer transcription factors are a recently defined class of transcription factors which can bind directly to nucleosomal DNA; they play a key role in gene activation in certain pathways. Here we quantify their role in… read more here.
Keywords: pioneer transcription; transcription; chromatin remodeling; kinetic proofreading ... See more keywords
MAF functions as a pioneer transcription factor that initiates and sustains myelomagenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Blood advances"
DOI: 10.1182/bloodadvances.2023009772
Abstract: Deregulated expression of lineage-affiliated transcription factors is a major mechanism of oncogenesis. However, how deregulation of non-lineage affiliated TF impacts chromatin to initiate oncogenic transcriptional programmes is not well known. To address this, we studied… read more here.
Keywords: pioneer transcription; oncogenic maf; transcription; maf ... See more keywords