2-(Pyridin-2-yl)isopropyl (PIP) Amine: An Enabling Directing Group for Divergent and Asymmetric Functionalization of Unactivated Methylene C(sp3)-H Bonds.
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DOI: 10.1021/acs.accounts.1c00168
Abstract: ConspectusDirecting group (DG) assistance provides a good solution to the problems of reactivity and selectivity, two of the fundamental challenges in C(sp3)-H activation. However, the activation of unbiased methylene C(sp3)-H bonds remains challenging due to… read more here.
Keywords: pip amine; methylene sp3; group; sp3 bonds ... See more keywords