Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference
Sign Up to like & getrecommendations! Published in 2017 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-017-1372-5
Abstract: The caged xanthone gambogic acid (GA) is a novel anti-cancer agent which exhibits anti-proliferative, anti-inflammatory and cytotoxic effects in many types of cancer tissues. In a recent phase IIa study, GA exhibits a favourable safety… read more here.
Keywords: kir2; kir2 kir2; pip2; inhibition ... See more keywords
Interaction of KRas4b with anionic membranes: A special role for PIP2.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.04.063
Abstract: KRas4b is a small G-protein whose constitutively active oncogenic mutants are present in 90% of pancreatic cancers. Using fully post-translationally modified KRAS4b, we investigated the role of lipid identity in the recruitment of KRas4b to… read more here.
Keywords: pip2; interaction kras4b; kras4b anionic; role ... See more keywords
Hydrogen Sulfide (H2S) Regulation of Kir (Inwardly Rectifying K+) Channels
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1248
Abstract: Inwardly rectifying potassium channels establish and regulate the resting membrane potential of excitable cells in tissues such as brain and heart. A wealth of electrophysiological, structural, and biochemical studies has revealed that a biological phospholipid,… read more here.
Keywords: cysteine; pip2; channel pip2; h2s ... See more keywords
Immobilization of Phosphatidylinositides Revealed by Bilayer Leaflet Decoupling.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c03800
Abstract: Phosphatidylinositol 4,5-bisphosphate (PIP2) has a significantly lower mobile fraction than most other lipids in supported lipid bilayers (SLBs). Moreover, the fraction of mobile PIP2 continuously decreases with time. To explore this, a bilayer unzipping technique… read more here.
Keywords: phosphatidylinositides revealed; immobilization phosphatidylinositides; pip2; mobile pip2 ... See more keywords
Conformational rearrangements in the second voltage sensor domain switch PIP2- and voltage-gating modes in two-pore channels.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209569120
Abstract: Two-pore channels (TPCs) are activated by phosphatidylinositol bisphosphate (PIP2) binding to domain I and/or by voltage sensing in domain II (DII). Little is known about how these two stimuli are integrated, and how each TPC… read more here.
Keywords: pore channels; voltage; domain; two pore ... See more keywords
Ca2+-Calmodulin and PIP2 interactions at the proximal C-terminus of Kv7 channels
Sign Up to like & getrecommendations! Published in 2017 at "Channels"
DOI: 10.1080/19336950.2017.1388478
Abstract: ABSTRACT In the heart, co-assembly of Kv7.1 with KCNE1 produces the slow IKS potassium current, which repolarizes the cardiac action potential and mutations in human Kv7.1 and KCNE1 genes cause cardiac arrhythmias. The proximal Kv7.1… read more here.
Keywords: ca2 calmodulin; cam; terminus; pip2 ... See more keywords
Nir1 constitutively localizes at ER–PM junctions and promotes Nir2 recruitment for PIP2 homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e21-07-0356
Abstract: Homeostatic regulation of plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate (PIP2) in receptor-stimulated cells is mediated by the lipid transfer protein Nir2. Nir2 is dynamically recruited to endoplasmic reticulum–plasma membrane (ER–PM) junctions to facilitate replenishment of PM… read more here.
Keywords: constitutively localizes; pip2 homeostasis; localizes junctions; pip2 ... See more keywords
Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP2
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.add1268
Abstract: The transient receptor potential melastatin 8 (TRPM8) channel is the primary molecular transducer responsible for the cool sensation elicited by menthol and cold in mammals. TRPM8 activation is controlled by cooling compounds together with the… read more here.
Keywords: channel; microscopy; trpm8; pip2 ... See more keywords
Phosphatidylinositol 4,5-bisphosphate regulates cilium transition zone maturation in Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.218297
Abstract: ABSTRACT Cilia are cellular antennae that are essential for human development and physiology. A large number of genetic disorders linked to cilium dysfunction are associated with proteins that localize to the ciliary transition zone (TZ),… read more here.
Keywords: pip2; maturation; phosphatidylinositol; transition zone ... See more keywords
Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0186293
Abstract: The slow delayed-rectifier potassium current (IKs) is crucial for human cardiac action potential repolarization. The formation of IKs requires co-assembly of the KCNQ1 α-subunit and KCNE1 β-subunit, and mutations in either of these subunits can… read more here.
Keywords: pip2; kcne1 channel; channel; kcnq1 kcne1 ... See more keywords
Hederasaponin C Alleviates Lipopolysaccharide-Induced Acute Lung Injury In Vivo and In Vitro Through the PIP2/NF-κB/NLRP3 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.846384
Abstract: Gene transcription is governed by epigenetic regulation that is essential for the pro-inflammatory mediators surge following pathological triggers. Acute lung injury (ALI) is driven by pro-inflammatory cytokines produced by the innate immune system, which involves… read more here.
Keywords: signaling pathway; nlrp3 signaling; lung injury; pip2 nlrp3 ... See more keywords