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   Articles with "pip3" as a keyword



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Increased PIP3 activity blocks nanoparticle mRNA delivery

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recommendations! Published in 2020 at "Science Advances"

DOI: 10.1126/sciadv.aba5672

Abstract: PIP3, a bioactive lipid upstream of the PI3K/AKT/mTOR pathway, decreased protein translated from nanoparticle-delivered mRNA. The biological pathways that affect drug delivery in vivo remain poorly understood. We hypothesized that altering cell metabolism with phosphatidylinositol… read more here.

Keywords: mrna delivery; delivery; pip3 activity; pip3 ... See more keywords
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Pipped to the pleckstrin threshold

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recommendations! Published in 2019 at "Science"

DOI: 10.1126/science.364.6443.847-d

Abstract: Signaling Bruton's tyrosine kinase (Btk) is a key player in B cell signaling and is a target in treating some lymphomas and leukemias. An early step in the signaling pathway is the generation of phosphatidylinositol… read more here.

Keywords: pipped pleckstrin; pleckstrin threshold; pip3;
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Identification of a Conserved Intracellular Loop (CIL) Structure That Scaffolds PIP3 to Amplify Oncogenic Signaling during Malignant B-Cell Transformation

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recommendations! Published in 2021 at "Blood"

DOI: 10.1182/blood-2021-149646

Abstract: Background: Within seconds of antigen-encounter, B-cell receptor (BCR) signaling induces dramatic changes of cell membrane lipid composition, including >40-fold increases of local PIP3-concentrations within lipid rafts. While several structural elements, including pleckstrin homology (PH) domains… read more here.

Keywords: activation; pip3; ifitm3; transformation ... See more keywords
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Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides

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recommendations! Published in 2018 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2018.00931

Abstract: One of the most paramount receptor-induced signal transduction mechanisms in hematopoietic cells is production of the lipid second messenger phosphatidylinositol(3,4,5)trisphosphate (PIP3) by class I phosphoinositide 3 kinases (PI3K). Defective PIP3 signaling impairs almost every aspect… read more here.

Keywords: cell development; pip3; function; development function ... See more keywords

Phospholipid Scramblase 4 (PLSCR4) Regulates Adipocyte Differentiation via PIP3-Mediated AKT Activation

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23179787

Abstract: Phospholipid scramblase 4 (PLSCR4) is a member of a conserved enzyme family with high relevance for the remodeling of phospholipid distribution in the plasma membrane and the regulation of cellular signaling. While PLSCR1 and -3… read more here.

Keywords: pip3; phospholipid scramblase; adipose tissue; scramblase plscr4 ... See more keywords