Increased PIP3 activity blocks nanoparticle mRNA delivery
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DOI: 10.1126/sciadv.aba5672
Abstract: PIP3, a bioactive lipid upstream of the PI3K/AKT/mTOR pathway, decreased protein translated from nanoparticle-delivered mRNA. The biological pathways that affect drug delivery in vivo remain poorly understood. We hypothesized that altering cell metabolism with phosphatidylinositol… read more here.
Keywords: mrna delivery; delivery; pip3 activity; pip3 ... See more keywords