PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation
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DOI: 10.1093/jmcb/mjz028
Abstract: Abstract PIP5k1β is crucial to the generation of phosphotidylinosotol (4, 5)P2. PIP5k1β participates in numerous cellular activities, such as B cell and platelet activation, cell phagocytosis and endocytosis, cell apoptosis, and cytoskeletal organization. In the… read more here.
Keywords: osteoclast osteoblast; bone homeostasis; pip5k1; differentiation ... See more keywords
Pip5k1γ promotes anabolism of nucleus pulposus cells and intervertebral disc homeostasis by activating CaMKII‐Ampk pathway in aged mice
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DOI: 10.1111/acel.14237
Abstract: Degenerative disc disease (DDD) represents a significant global health challenge, yet its underlying molecular mechanisms remain elusive. This study aimed to investigate the role of type 1 phosphatidylinositol 4‐phosphate 5‐kinase (Pip5k1) in intervertebral disc (IVD)… read more here.
Keywords: pip5k1; intervertebral disc; homeostasis; ampk pathway ... See more keywords