Persistence of piperacillin concentrations after treatment discontinuation: in cauda venenum?
Sign Up to like & getrecommendations! Published in 2018 at "Intensive Care Medicine"
DOI: 10.1007/s00134-018-5479-z
Abstract: Dear Editor, Antibiotic therapy is the mainstay of the treatment of severe infections. Antibiotics are administered as long as therapeutic drug concentrations are required, typically 5–10 days for most infections [1]. Due to changes in… read more here.
Keywords: piperacillin concentrations; piperacillin; treatment; treatment discontinuation ... See more keywords
Saturable elimination of piperacillin in critically ill patients: implications for continuous infusion.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.08.024
Abstract: PURPOSE To evaluate saturation of piperacillin elimination in adult critically ill patients. PATIENTS AND METHODS Seventeen adult critically ill patients received continuous and intermittent infusion piperacillin/tazobactam. Piperacillin plasma concentrations (n=217) were analyzed using population pharmacokinetic… read more here.
Keywords: piperacillin critically; infusion; piperacillin; ill patients ... See more keywords
Population pharmacokinetics of continuous infusion piperacillin/tazobactam in very elderly hospitalized patients and considerations for target attainment against Enterobacterales and Pseudomonas aeruginosa.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2021.106408
Abstract: Continuous infusion (CI) piperacillin/tazobactam is frequently used to treat infections in very elderly patients. The aims is to conduct a population pharmacokinetic analysis of CI piperacillin/tazobactam and to identify optimal dosages for safe and effective… read more here.
Keywords: permissible doses; continuous infusion; piperacillin; piperacillin tazobactam ... See more keywords
Tazobactam-Piperacillin Associated Transient Neutropenia and Thrombocytopenia.
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Therapeutics"
DOI: 10.1097/mjt.0000000000001255
Abstract: To the Editor: Piperacillin–tazobactam is a commonly prescribed broadspectrum antibiotic especially in inpatient settings for polymicrobial coverage. It is a penicillin and a beta-lactamase inhibitor combination. It has coverage against gramnegative bacteria including pseudomonas and… read more here.
Keywords: patient; tazobactam piperacillin; count; thrombocytopenia ... See more keywords
Piperacillin/tazobactam vs carbapenems for patients with bacterial infection: Protocol for a systematic review
Sign Up to like & getrecommendations! Published in 2019 at "Acta Anaesthesiologica Scandinavica"
DOI: 10.1111/aas.13382
Abstract: Early empirical broad‐spectrum antimicrobial therapy is recommended for patients with severe infections, including sepsis. β‐lactam/β‐lactamase inhibitor combinations or carbapenems are often used to ensure coverage of likely pathogens. Piperacillin/tazobactam is proposed as a carbapenem‐sparing agent… read more here.
Keywords: tazobactam carbapenems; patients severe; piperacillin; piperacillin tazobactam ... See more keywords
Linear IgA bullous dermatosis secondary to piperacillin‐tazobactam
Sign Up to like & getrecommendations! Published in 2021 at "Dermatologic Therapy"
DOI: 10.1111/dth.15232
Abstract: Dear Editor, A 69-year-old woman presented to our hospital due to intense 72 hlong abdominal pain. After performing an urgent computed tomography angiography, a superior mesenteric venous thrombosis was detected. She had a history of… read more here.
Keywords: iga bullous; piperacillin tazobactam; bullous dermatosis; linear iga ... See more keywords
Using Population Pharmacokinetic Modeling and Monte Carlo Simulations To Determine whether Standard Doses of Piperacillin in Piperacillin-Tazobactam Regimens Are Adequate for the Management of Febrile Neutropenia
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00311-17
Abstract: ABSTRACT Changes in the pharmacokinetics of piperacillin in febrile neutropenic patients have been reported to result in suboptimal exposures. This study aimed to develop a population pharmacokinetic model for piperacillin and perform dosing simulation to… read more here.
Keywords: piperacillin; monte carlo; population pharmacokinetic; febrile neutropenia ... See more keywords
Antibiotic drug piperacillin induces neuron cell death through mitochondrial dysfunction and oxidative damage.
Sign Up to like & getrecommendations! Published in 2018 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2016-0679
Abstract: Although nerve damage/toxicity has been shown to be one of the side effects in patients given prolonged antibiotic treatment, the mechanisms of the action of antibiotics on neuron cells are not clear. In this work,… read more here.
Keywords: piperacillin; oxidative damage; neuron cells; damage ... See more keywords
Systematic Review of Piperacillin-Tazobactam and Vancomycin Y-Site Compatibility: Consideration of Concentration and Solution Variability
Sign Up to like & getrecommendations! Published in 2023 at "Hospital Pharmacy"
DOI: 10.1177/00185787231169455
Abstract: Simultaneous administration of vancomycin and piperacillin-tazobactam (VPT) poses significant challenges related to physical and chemical compatibility, as well as clinical practice. A systematic review of available literature related to VPT Y-site compatibility was performed. Data… read more here.
Keywords: piperacillin; review; compatibility; site ... See more keywords
Comparison of the Nephrotoxicity of Vancomycin in Combination With Cefepime, Meropenem, or Piperacillin/Tazobactam: A Prospective, Multicenter Study
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Pharmacotherapy"
DOI: 10.1177/1060028018757497
Abstract: Background: Patients often receive broad-spectrum antibiotics for nosocomial infections commonly with activity against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus. Previous retrospective and/or single-center studies have suggested that the combination of vancomycin and piperacillin/tazobactam might be… read more here.
Keywords: piperacillin tazobactam; piperacillin; cefepime meropenem; combination ... See more keywords
Serologic Characterization of Antibodies in Patients Experiencing Piperacillin-Induced Immune Thrombocytopenia
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-130966
Abstract: Beta lactam antibiotics (penicillins, cephalosporins, etc) are relatively common triggers for immune hemolytic anemia, neutropenia and drug-induced thrombocytopenia (DITP) but the mechanism(s) responsible for this side effect are not well understood. The ureidopenicillin, piperacillin, is… read more here.
Keywords: thrombocytopenia; piperacillin induced; piperacillin; piperacillin coated ... See more keywords