Novel piperazine based compounds as potential inhibitors for SARS-CoV-2 Protease Enzyme: Synthesis and molecular docking study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131020
Abstract: Structurally diverse piperazine-based compounds hybrid with thiadiazole, isatin or with sulfur/nitrogen, functionalities were synthesized. The structures of the new compounds were established based on their spectral data and elemental analysis. The physicochemical, bioactivity scores and… read more here.
Keywords: protease; cov protease; protease enzyme; piperazine based ... See more keywords
Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0006183
Abstract: Cryptosporidiosis causes life-threatening diarrhea in infants, but the best available treatment is only modestly efficacious. Rodents infected with relevant Cryptosporidium species do not develop diarrhea, which complicates drug development. Cryptosporidium parvum infection of dairy calves,… read more here.
Keywords: clinical microbiologic; drug; piperazine based; efficacy piperazine ... See more keywords