Neuropharmacological assessment in mice and molecular docking of piperazine derivative LQFM212
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112827
Abstract: Piperazine derivatives are an attractive class of chemical compounds for the treatment of various mental illness. Herein, we demonstrated the synthesis of LQFM212, a piperazine derivative, behavioral evaluation in mice and computational studies. In neuropharmacological… read more here.
Keywords: piperazine derivative; neuropharmacological assessment; lqfm212; anxiolytic like ... See more keywords
Discovery of a novel piperazine derivative, cmp2: a selective TRPC6 activator suitable for treatment of synaptic deficiency in Alzheimer’s disease hippocampal neurons
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DOI: 10.1038/s41598-024-73849-z
Abstract: Alzheimer disease (AD) is characterized by progressive loss of memory. Synaptic loss is now the best correlate of cognitive dysfunction in patients with Alzheimer’s disease. Thus, restoration or limitation of synapse loss is a promising… read more here.
Keywords: alzheimer disease; trpc6; cmp2; novel piperazine ... See more keywords