Piperazine derivatives with potent drug moiety as efficient acetylcholinesterase, butyrylcholinesterase, and glutathione Sâtransferase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23259
Abstract: Cholinesterases catalyze the breakdown of the neurotransmitter acetylcholine (ACh), a naturally occurring neurotransmitter, into choline and acetic acid, allowing the nervous system to function properly. In the human body, cholinesterases come in two types, including… read more here.
Keywords: piperazine derivatives; ache bche; bche; butyrylcholinesterase ... See more keywords
Crystallographic studies of piperazine derivatives of 3-methyl-5-spirofluorenehydantoin in search of structural features of P-gp inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Acta crystallographica. Section C, Structural chemistry"
DOI: 10.1107/s2053229621006756
Abstract: 5-Spirofluorenehydantoin derivatives show efflux modulating, cytotoxic and antiproliferative effects in sensitive and resistant mouse T-lymphoma cells. In order to extend the knowledge available about the pharmacophoric features responsible for the glycoprotein P (P-gp) inhibitory properties… read more here.
Keywords: crystallographic studies; derivatives methyl; spirofluorenehydantoin search; methyl spirofluorenehydantoin ... See more keywords
Enantioselective Henry Reaction Catalyzed by Chiral Piperazine Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2021.7150
Abstract: A series of novel tridentate Schiff bases is synthesized from piperazine-amine and substituted salicylaldehydes, and characterized by spectroscopic methods. These chiral ligands were used to catalyze the addition of nitromethane to various aldehydes in the… read more here.
Keywords: henry reaction; piperazine derivatives; catalyzed chiral; chiral piperazine ... See more keywords
2D & 3D-QSAR Study on Novel Piperidine and Piperazine Derivatives as Acetylcholinesterase Enzyme Inhibitors.
Sign Up to like & getrecommendations! Published in 2018 at "Current computer-aided drug design"
DOI: 10.2174/1573409914666180726092800
Abstract: INTRODUCTION Acetylcholinesterase enzyme (AChE) is the main target in Alzheimer's disease therapy and designing of novel AChE inhibitors is a great deal of attention. METHODS In this study, 2D-QSAR and 3D-QSAR models were generated using… read more here.
Keywords: study novel; piperazine derivatives; novel piperidine; piperidine piperazine ... See more keywords