Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors.
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DOI: 10.1021/acs.jmedchem.8b00824
Abstract: Monoacylglycerol lipase (MAGL) is a major serine hydrolase that hydrolyzes 2-arachidonoylglycerol (2-AG) to arachidonic acid (AA) and glycerol in the brain. Because 2-AG and AA are endogenous biologically active ligands in the brain, inhibition of… read more here.
Keywords: piperazinyl pyrrolidin; pyrrolidin ones; piperazinyl; monoacylglycerol lipase ... See more keywords